98155-24-9

Basic information

• Product Name: ethyl (R)-(-)-2-oxo-4-thiazolidinecarboxylate
• Synonyms: ethyl (R)-(-)-2-oxo-4-thiazolidinecarboxylate
• CAS NO: 98155-24-9
• Molecular Formula: C₆H₉NO₃S
• Molecular Weight: 175.21
• Mol File: 98155-24-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl (R)-(-)-2-oxo-4-thiazolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (R)-(-)-2-oxo-4-thiazolidinecarboxylate(98155-24-9)
• EPA Substance Registry System: ethyl (R)-(-)-2-oxo-4-thiazolidinecarboxylate(98155-24-9)

Safety Data

• Hazardous Substances Data: 98155-24-9(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 64-17-5 ethanol 
• 19771-63-2 2-oxothiazolidine-4(R)-carboxylic acid 
• 868-59-7 chlorhydrate du L-cysteinate d'ethyle 
• 530-62-1 1,1'-carbonyldiimidazole 
• 3411-58-3 L-cystein ethyl ester 
• 124-38-9 carbon dioxide 
• 76343-92-5 (R)-4-((4Z,8E,10Z)-(1R,12S,15R)-5,12-Dimethyl-3-oxo-2,16-dioxa-bicyclo[13.3.1]nonadeca-4,8,10,17-tetraen-17-yl)-thiazolidin-2-one 

Downstream Products

• 101860-50-8 (-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid ethyl ester 
• 264621-75-2 ethyl (4R)-3-but-3-enyl-2-oxothiazolidine-4-carboxylate 
• 98183-20-1 (R)-3-benzyl-2-oxothiazolidine-4-carboxylic acid ethyl ester 
• 19750-45-9 l-2-oxothiazolidine-4-carboxylic acid 

Relevant articles and documents

Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity

Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occurring actin inhibitors such as latrunculins are a promising starting point. However, the limited availability of the natural product and the laborious route for synthesis of latrunculins have hindered their potential development as drug candidates. In this regard, we recently described novel truncated latrunculins, with superior actin binding potency and selectivity towards P. falciparum actin than the canonical latrunculin B. In this paper, we further explore the truncated latrunculin core to summarize the SAR for inhibition of malaria motility. This study helps further understand the binding pattern of these analogues in order to develop them as drug candidates for malaria.

(R)-[(2-oxo-4-thiazolidinyl)methyl]triphenylphosphonium iodide: A wittig reagent for the synthesis of cysteine-derived alkenes

(R)-[(2-Oxo-4-thiazolidinyl)methyl]triphenylphosphonium iodide (1), readily prepared in five steps from l-cysteine ethyl ester (39% overall on a 500 g scale), is a useful Wittig reagent for the synthesis of cysteine-derived alkenes such as those found in

Carbonylation with CO2 and phosphorus electrophiles: A convenient method for the synthesis of 2-oxazolidinones from 1,2-amino alcohols

2-Oxazolidinones were prepared in good yields from 1,2-amino alcohols and CO2 in the presence of tetramethyl-phenylguanidine (PhTMG) as a base and a variety of phosphorus electrophiles under mild conditions. This procedure is advantageous over previous methodologies and relies on a novel carbonylation procedure that utilizes nontoxic CO2 and phosphorus electrophiles. Georg Thieme Verlag Stuttgart.