98187-13-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-trifluoromethylbenzoyl chloride is used as a reagent in organic synthesis for the preparation of various compounds, including anti-inflammatory drugs. Its unique structure contributes to the development of pharmaceuticals with specific therapeutic properties.
Used in Agrochemical Industry:
4-Chloro-2-trifluoromethylbenzoyl chloride is also utilized in the production of agrochemicals, serving as a key intermediate in the synthesis of pesticides. Its role in this industry is crucial for creating effective pest control solutions.
Used in Dye and Pigment Manufacturing:
4-Chloro-2-trifluoromethylbenzoyl chloride is used as a key intermediate in the manufacturing of dyes and pigments, contributing to the creation of a wide range of colorants for various applications.
Used in Perfumery:
In the perfume industry, it is used as a building block for the synthesis of various perfume ingredients, enhancing the fragrance profiles of different scents.
Safety Note:
Due to its highly reactive nature, 4-Chloro-2-trifluoromethylbenzoyl chloride should be handled with caution. It can cause skin and eye irritation upon contact, necessitating proper safety measures during its use in various applications.

InChI:InChI=1/C8H3Cl2F3O/c9-4-1-2-5(7(10)14)6(3-4)8(11,12)13/h1-3H

Upstream product

• 142994-09-0 4-chloro-2-(trifluoromethyl)benzoic acid 
• 157229-44-2 o-trifluoromethyl-4-chloro-α,α-dichlorotoluene 
• 320-43-4 4-chloro-2-(trifluoromethyl)benzaldehyde 
• 615-60-1 4-chloro-1,2-dimethylbenzene 

Downstream Products

• 873846-14-1 4-chloro-N,N-diethyl-2-(trifluoromethyl)benzamide 
• 1254073-55-6 4-{[4-chloro-2-(trifluoromethyl)phenyl]carbonyl}-2-piperazinone 

Relevant academic research and scientific papers

Intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as preparation method and application of intermediate compound

The invention relates to an intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as a preparation method and application of the intermediate compound. The intermediate compound is 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate, 3, 4-dimethylchlorobenzene is taken as an initial raw material, and the intermediate compound is obtained by chlorination, fluorine-chlorine exchange reaction, hydrolysis, continuous chlorination and coupling with malonate. The intermediate compound 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate is subjected to hydrolysis decarboxylation to obtain 4-chloro-2-trifluoromethyl-acetophenone, the raw materials in the route are easy to obtain, dangerous reactions such as nitration and Grignard reaction are avoided, and the method is suitable for industrial production.

2-benzoyl malonate compound as well as preparation method and application thereof

The invention discloses a 2-benzoyl malonate compound as well as a preparation method and application thereof. The invention provides a preparation method of an acetylbenzene compound shown as a formula III. The preparation method comprises the following step: in an organic solvent, in the presence of an acid and water, carrying out a deesterification reaction as shown in the specification on a 2-benzoyl malonate compound as shown in a formula I and/or a tautomer thereof to obtain the acetylbenzene compound as shown in a formula III, wherein X is F, Cl, Br or I; wherein R1 and R2 are each independently a C1-C4 alkyl group. By adopting the 2-benzoyl malonate compound disclosed by the invention, 4-halogenated-2-trifluoromethyl acetophenone can be prepared through one-step reaction, and the operation is simple and convenient.

Pyrrolo(oxo)isoquinolines as 5HT ligands

The present application describes compounds according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at least one additional therapeutic agent and methods of treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using compounds according to Formula I or pharmaceutically acceptable salt forms thereof, wherein A, B, D, E, m, n, R3, R7, R8, R9, R10, R11 and X are described herein.