98187-17-8

Usage

Uses

Used in Pharmaceutical Industry:
4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is used as a reagent for the synthesis of pharmaceuticals due to its ability to introduce the benzoate protecting group and participate in key reactions such as acylation and Friedel-Crafts reactions.
Used in Agrochemical Industry:
In the agrochemical industry, 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is used as an intermediate in the production of various agrochemicals, taking advantage of its reactivity in organic synthesis.
Used in Dye and Perfume Manufacturing:
4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is used as a key component in the manufacture of dyes and perfumes, where its reactivity allows for the creation of a wide range of organic compounds with desired properties.
Used in Organic Synthesis:
As a versatile reagent in organic synthesis, 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is used for the introduction of the benzoate protecting group, which is essential in various chemical reactions and the synthesis of complex organic molecules.

Upstream product

• 127817-85-0 4-methoxy-2-(trifluoromethyl)benzoic acid 
• 454-90-0 3-(trifluoromethyl)anisole 

Downstream Products

• 127817-92-9 N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-methoxy-2-trifluormethylbenzamid 
• 127817-97-4 N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxy-2-trifluormethylbenzamid 

Relevant academic research and scientific papers

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents

New phenothiazine derivatives 6-20 have been designed, synthesized and evaluated in vitro for their ability to inhibit tubulin polymerization and antiproliferative activity against 60 cancer cell lines, including several multi-drug resistant (MDR) tumor cell lines. The phenothiazine unit may successfully replace the classical 3,4,5-trimethoxyphenyle A ring of parent combretastatin A-4 or phenstatin, confirming previous studies. The most promising structural modulations have been realized on the B ring, the 2′-fluoro-4′-methoxy substitution in compound 6 and the 2′-trifluoromethyl-4′-methoxy substitution in compound 7 providing the best antitubulin and antitumor activity in the current study. Compounds 6-8 and 16 exhibited more important cell growth inhibition than parent phenstatin 2 on human colon Duke's type D, colorectal adenocarcinoma COLO 205 and on human kidney adenocarcinoma A498 cell lines. 10-Methylphenothiazine derivatives 19 and 20 did not show biological activity but exerted bright fluorescence and solvatochromism effects. These molecules deserve further chemical efforts in order to provide valuable tools for biophysical studies.

AROMATIC HETEROCYCLIC COMPOUND

The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and the like; X is a single bond and the like; Y is alkyl which may be substituted and the like; Z is CR1 or nitrogen atom; R1 is hydrogen and the like; R2 is alkyl which may be substituted and the like or a pharmaceutically acceptable salt thereof is useful as a prevention/treatment agent of obesity, diabetes, and the like.

Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: Influence of hydrophobic groups substituted in the ortho-position of the benzamide-fragment on activity

Experiments are reported here to develop compounds with antiestrogenic and mammary tumor inhibiting properties. Analogues with hydrophobic groups in 2- or 2,6-position of the benzamide-fragment of N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxy