98187-17-8

Basic information

• Product Name: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• CAS NO: 98187-17-8
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.5909496
• Mol File: 98187-17-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Refractive Index: 1.5145
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(98187-17-8)
• EPA Substance Registry System: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(98187-17-8)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 98187-17-8(Hazardous Substances Data)

Usage

General Description

4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is a chemical compound that is commonly used in organic synthesis as a reagent for the introduction of the benzoate protecting group. It is a benzoyl chloride derivative with a methoxy and trifluoromethyl group attached to the benzene ring. 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is highly reactive and can undergo reactions such as acylation and Friedel-Crafts reactions, making it useful in the production of pharmaceuticals and agrochemicals. It is also used in the manufacture of dyes, perfumes, and other organic compounds. Additionally, it is important to handle this chemical with care, as it is corrosive and can cause severe skin and eye irritation.

Upstream product

• 454-90-0 3-(trifluoromethyl)anisole 
• 127817-85-0 4-methoxy-2-(trifluoromethyl)benzoic acid 

Downstream Products

• 127817-97-4 N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxy-2-trifluormethylbenzamid 
• 127817-92-9 N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-methoxy-2-trifluormethylbenzamid 

Relevant articles and documents

Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents

New phenothiazine derivatives 6-20 have been designed, synthesized and evaluated in vitro for their ability to inhibit tubulin polymerization and antiproliferative activity against 60 cancer cell lines, including several multi-drug resistant (MDR) tumor cell lines. The phenothiazine unit may successfully replace the classical 3,4,5-trimethoxyphenyle A ring of parent combretastatin A-4 or phenstatin, confirming previous studies. The most promising structural modulations have been realized on the B ring, the 2′-fluoro-4′-methoxy substitution in compound 6 and the 2′-trifluoromethyl-4′-methoxy substitution in compound 7 providing the best antitubulin and antitumor activity in the current study. Compounds 6-8 and 16 exhibited more important cell growth inhibition than parent phenstatin 2 on human colon Duke's type D, colorectal adenocarcinoma COLO 205 and on human kidney adenocarcinoma A498 cell lines. 10-Methylphenothiazine derivatives 19 and 20 did not show biological activity but exerted bright fluorescence and solvatochromism effects. These molecules deserve further chemical efforts in order to provide valuable tools for biophysical studies.

Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: Influence of hydrophobic groups substituted in the ortho-position of the benzamide-fragment on activity

Experiments are reported here to develop compounds with antiestrogenic and mammary tumor inhibiting properties. Analogues with hydrophobic groups in 2- or 2,6-position of the benzamide-fragment of N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxy