127817-85-0

Basic information

• Product Name: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: RARECHEM AL BE 1192;4-METHOXY-2-(TRIFLUOROMETHYL)BENZOIC ACID;2-(Trifluoromethyl)-4-methoxybenzoic acid;2-(Trifluoromethyl)-p-anisic acid, 2-Carboxy-5-methoxybenzotrifluoride, 4-Carboxy-3-(trifluoromethyl)anisole
• CAS NO: 127817-85-0
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid
• Mol File: 127817-85-0.mol

Chemical Properties

• Melting Point: 147-150°C
• Boiling Point: 274.816 °C at 760 mmHg
• Flash Point: 120.004 °C
• Appearance: White powder
• Density: 1.38 g/cm³
• Vapor Pressure: 0.00256mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.50±0.36(Predicted)
• CAS DataBase Reference: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOIC ACID(127817-85-0)
• EPA Substance Registry System: 4-METHOXY-2-(TRIFLUOROMETHYL)BENZOIC ACID(127817-85-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 127817-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-2-(trifluoromethyl)benzoic acid is used as a reactant for the synthesis of phenothiazines, which are a class of chemical compounds that include various drugs with a wide range of applications, particularly in the treatment of psychiatric disorders such as schizophrenia and bipolar disorder. The unique structure of 4-Methoxy-2-(trifluoromethyl)benzoic acid allows for the creation of phenothiazine derivatives with potentially improved pharmacological properties.
Used in Chemical Synthesis:
In the field of organic chemistry, 4-Methoxy-2-(trifluoromethyl)benzoic acid can be utilized as a building block or intermediate for the synthesis of various other complex organic molecules. Its specific functional groups and trifluoromethyl substitution may offer advantages in the development of novel compounds with tailored properties for different applications, such as agrochemicals, dyes, or advanced materials.

InChI:InChI=1/C9H7F3O3/c1-15-5-2-3-6(8(13)14)7(4-5)9(10,11)12/h2-4H,1H3,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 454-90-0 3-(trifluoromethyl)anisole 
• 400-72-6 3-trifluoromethyl-4-bromo-1-methoxy-benzene 

Downstream Products

• 98187-17-8 4-Methoxy-2-trifluormethylbenzoesaeurechlorid 
• 127817-97-4 N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxy-2-trifluormethylbenzamid 
• 127817-92-9 N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-methoxy-2-trifluormethylbenzamid 
• 320-32-1 4-hydroxy-2-(trifluoromethyl)benzoic acid 
• 400-72-6 3-trifluoromethyl-4-bromo-1-methoxy-benzene 

Relevant articles and documents

2-trifluoromethyl-4-hydroxybenzoic acid

Disclosed is a novel compound 2-trifluoromethyl-4-hydroxybenzoic acid represented by the formula: STR1

Process for the preparation of 2-trifluoromethyl-4-hydroxybenzoic acid

Disclosed is a novel compound 2-trifluoromethyl--4-hydroxybenzoic acid represented by the formula:

Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: Influence of hydrophobic groups substituted in the ortho-position of the benzamide-fragment on activity

Experiments are reported here to develop compounds with antiestrogenic and mammary tumor inhibiting properties. Analogues with hydrophobic groups in 2- or 2,6-position of the benzamide-fragment of N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxy