98193-34-1Relevant academic research and scientific papers
Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
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, (2008/06/13)
The invention relates to compounds of the formula: STR1 which are useful as leukotriene D4 (LTD4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
Substituted dihydrobenzopyran-2-carboxylates
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, (2008/06/13)
The invention relates to substituted dihydrobenzopyrans carboxylates of the formula: STR1 wherein A is a methylene chain having 1-10 carbon atoms, inclusive, optionally substituted by hydroxy; wherein V is: (a) hydrogen; (b) hydroxy; (c) =O; or (d) R6 CH2 O--; wherein R1 is: (a) --COCH3 ; (b) --CHOHCH3 ; (c) --C2 H5 ; (d) -hydrogen; or (e) --COOC2 H5 wherein R2 is: (a) -hydrogen; (b) -hydroxy; or (c) R12 CH2 CO2 --; wherein R3, R4, R6, R7, R8, R9, R10, R11 and R12 each of which may be the same or different, are: (a) hydrogen; (b) lower-alkyl having 1-6 carbon atoms inclusive; or (c) allyl; wherein R5 is: (a) hydrogen; or (b) R7 CH2 C(O)--; wherein R13 is hydrogen, hydroxy, alkoxy of 1 to 6 carbon atoms inclusive, or --OM wherein M is an alkali metal, alkyl of 1 to 6 carbon atoms, inclusive, or NR8≈ R9 R10 R11, or HNR8≈ R9 R10, or the pharmacologically acceptable addition salts thereof, which are useful as leukotriene D4 (LTD4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
