98230-35-4Relevant academic research and scientific papers
N- AND O-CARBAMOYL AND THIOCARBAMOYL DERIVATIVES OF &β-LACTAM ANTIBIOTICS
Petrulyanis, L. N.,Veinberg, G. A.,Kononov, L. I.,Dreibante, I. I.,Lukevits, E. Ya.
, p. 279 - 282 (2007/10/02)
New N-acylureido and N-acylthioureido derivatives of β-lactam antibiotics were obtained by the reaction of 6-ureido and 6-thioureidopenicillanic and 7-thioreidodeacetoxycephalosporanic acids with acyl halides of carboxylic acids and benzoyl isocyanate. 6-Carbamoylhydroxypenicillanic acid, 6-thiocarbamoylhydroxypenicillanic acid, and its trichloroethyl ester were obtained by treatment of 6-α-hydroxypenicillanic acid and its trichloroethyl ester with isocyanatosilanes with subsequent hydrolysis of the N-silylcyanato groups.
