98244-11-2

Upstream product

• 145163-09-3 (E)-(2S,3R)-3-Hydroxy-1-[(3S,4S)-5-((E)-(2S,3R)-3-hydroxy-2-methyl-hex-4-enoyl)-1,1-dioxo-3,4-diphenyl-1λ⁶-[1,2,5]thiadiazolidin-2-yl]-2-methyl-hex-4-en-1-one 
• 186581-53-3 diazomethane 
• 125665-02-3 N-<(2S,3R)-2-methyl-3-hydroxy-(E)-4-hexenoyl>bornane-10,2-sultam 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

Asymmetric aldol reactions employing a cyclic sulfamide chiral auxiliary

A titanium enolate derived from (3S,4S)-2,5-dipropionyl-3,4-diphenyl-1,2,5-thiadiazolidine 1,1-dioxide (3) reacts with aldehydes to give syn aldols with high stereoselection (> 95:5).

Bornanesultam-directed asymmetric synthesis of crystalline, enantiomerically pure syn aldols

N-acylsultams 2 furnish, via aldolization of their enolates 16 with aldehydes, diastereomerically pure, crystalline syn aldols. The absolute configuration of the product is controlled by the choice of the enolate counterion: 16, M = B → 3; 16, M = Li or S