98244-61-2Relevant academic research and scientific papers
Total Synthesis of (-)-Crinine. Use of Tandem Cationic Aza-Cope Rearrangement/Mannich Cyclizations for the Synthesis of Enantiomerically Pure Amaryllidaceae Alkaloids
Overman, Larry E.,Sugai, Soji
, p. 745 - 749 (1985)
The total synthesis of enantiomerically pure (-)-crinine (1) in 10 steps and 6percent overall yield from cyclopentene oxide is reported.The key step was the rearrangement of 7 upon reaction with AgNO3 at 25 deg C to give cis-perhydroindolone 8 in 81 perce
