1452230-52-2

Upstream product

• 608-31-1 2,6-Dichloroaniline 
• 98276-75-6 4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid 
• 7234-25-5 4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1452230-54-4 6-(2,6-dichlorophenyl)-2-(methylthio)-8-((phenylamino)methyl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-55-5 6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-{[(2,2,2-trifluoroethyl)amino]methyl}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-56-6 6-(2,6-dichlorophenyl)-2-(methylthio)-8-((2,2,2-trifluoroethylamino)methyl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-57-7 8-(1,3-benzothiazol-2-yl)-6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-58-8 8-(benzo[d]thiazol-2-yl)-6-(2,6-dichlorophenyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-60-2 8-(1H-benzo[d]imidazol-2-yl)-6-(2,6-dichlorophenyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-59-9 8-(1H-benzimidazol-2-yl)-6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-64-6 6-(2,6-dichlorophenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde 
• 1452230-79-3 6-(2,6-dichlorophenyl)-8-(difluoromethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-80-6 6-(2,6-dichlorophenyl)-8-(difluoromethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-81-7 6-(2,6-dichlorophenyl)-8-(fluoromethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-82-8 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-83-9 6-(2,6-dichlorophenyl)-8-(fluoromethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-84-0 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 

Relevant academic research and scientific papers

Investigation of biaryl heterocycles as inhibitors of Wee1 kinase

In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ

2-AMINOPYRIDO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND THEIR USE AS WEE-1 INHIBITORS

The present invention relates to compounds of formula (I) that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds i

PYRIDOPYRIMIDINONE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions cont