98278-07-0

Upstream product

• 108-02-1 captamine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 7161-73-1 β-mercaptoethyltrimethylammonium iodide 
• 106536-45-2 2-bromo-N,N-dimethylethan-1-amine hydrochloride 
• 10387-40-3 potassium thioacetate 

Relevant academic research and scientific papers

Acetylthiocholine iodide as well as preparation method and application thereof

The invention provides acetylthiocholine iodide and a preparation method thereof. The preparation method comprises the following steps: step S1, dissolving a dimethylamino ethane compound in alkali toobtain an alkaline aqueous solution; step S2, adding a thioacetic acid compound into the alkaline aqueous solution to subject the thioacetic acid compound and the dimethylamino ethane compound to a thioreaction to generate (2-(dimethylamino)ethyl)ethanethioate; S3, separating the (2-(dimethylamino)ethyl)ethanethioate, and preparing an organic solution of the (2-(dimethylamino)ethyl)ethanethioate;and S4, dropwise adding an organic iodide into the organic solution of the (2-(dimethylamino)ethyl)ethanethioate for an iodination reaction so as to generate the acetylthiocholine iodide. According to the preparation method provided by the embodiment of the invention, the high-purity acetylthiocholine iodide can be obtained, and the titration content, the melting point, the clarity and other dataof the product are very excellent. The method is simple in operation, good in safety, suitable for industrial production, easy in raw material obtaining and low in cost.