98303-60-7

Basic information

• Product Name: threo-Hexuronic acid, 2,3-anhydro-4,5-dideoxy-, methyl ester (9CI)
• Synonyms: threo-Hexuronic acid, 2,3-anhydro-4,5-dideoxy-, methyl ester (9CI)
• CAS NO: 98303-60-7
• Molecular Formula: C7H10O4
• Molecular Weight: 158.1519
• Product Categories: ALDEHYDE
• Mol File: 98303-60-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: threo-Hexuronic acid, 2,3-anhydro-4,5-dideoxy-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: threo-Hexuronic acid, 2,3-anhydro-4,5-dideoxy-, methyl ester (9CI)(98303-60-7)
• EPA Substance Registry System: threo-Hexuronic acid, 2,3-anhydro-4,5-dideoxy-, methyl ester (9CI)(98303-60-7)

Safety Data

• Hazardous Substances Data: 98303-60-7(Hazardous Substances Data)

Upstream product

• 3878-55-5 methyl hydrogen succinate 
• 13865-19-5 4-oxobutanoic acid methyl ester 
• 1490-25-1 succinic acid monomethylester chloride 
• 98303-59-4 (E)-methyl 5-formylpent-4-enoate 

Relevant articles and documents

Synthesis and LTD4 antagonist activity of 2-norleukotriene analogues.

A series of structural analogues of 4(R)-hydroxy-5(S)-cysteinylglycyl-6(Z)-nonadecenoic acid [4R,5S,6Z)-2-nor-LTD1 (10b), SK&F 101132) has been synthesized and pharmacologically characterized. (4R,5S,6Z)-2-nor-LTD1 significantly antagonized LTD4-induced contractile responses on isolated guinea pig trachea. The cis double-bond geometry appears to be critical for antagonist activity, whereas the trans isomer 17 exhibited weak contractile activity. Replacement of the cysteinylglycyl moiety with cysteine afforded 20, which retained significant antagonist activity, while lengthening or shortening the lipid tail by five methylene groups resulted in complete loss of activity. The eicosanoid amide 15, glycinamide 14, and C-1 carbinol 18 analogues all possessed antagonist activity, whereas the diol derivative 19 exhibited increased intrinsic agonist activity.