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Usage

General Description

2H-Azepin-2-one, 1-(chloroacetyl)hexahydro- (9CI) is a chemical compound with the molecular formula C9H13ClO2. It is a chloroacetyl derivative of azepan-2-one, and it is also known as 1-(chloroacetyl)cycloheptanone. 2H-Azepin-2-one, 1-(chloroacetyl)hexahydro- (9CI) is a cyclic amide and a heterocyclic compound, and it is commonly used in organic synthesis and chemical research as a building block for the preparation of various organic compounds. It is also used as a starting material for the synthesis of pharmaceuticals and other biologically active molecules. Additionally, its ring structure and functional groups make it a valuable intermediate in the preparation of diverse heterocyclic compounds with potential pharmacological applications.

Upstream product

• 105-60-2 caprolactam 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 106420-70-6 2-oxo-N-phenyl-2,7,8,9,10,11-hexahydrocycloheptapyridine-4,5-dicarboximide 

Relevant academic research and scientific papers

Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore

New green fluorescent protein (GFP) chromophore analogues, namely 4-(diarylmethylene)imidazolinones (DAINs), were readily synthesized under weakly acidic conditions using a novel condensation reaction between methyl imidate (or thioimidate) and ethyl N-(diarylmethylene)glycinate. DAINs showed notable fluorescence properties. Although they were nearly non-fluorescent in the solution, visible emissions were detected in most of their frozen solution states and crystalline powder states. Therefore, control of the molecular motions significantly affected emissions by DAINs. Comparison of the fluorescence properties of DAIN 5a with those of the corresponding GFP-chromophore analogues 8 revealed that 5a possessed superior solid-state fluorescence properties.

Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro

We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.