98376-40-0

Upstream product

• 4457-32-3 4-nitrobenzyl chloroformate 
• 98376-38-6 {(E)-(R)-6-[(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hept-3-enyl}-carbamic acid 4-nitro-benzyl ester 
• 98376-37-5 (3R,4R)-3-(1-Fluoro-ethyl)-4-[(R)-1-methyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-azetidin-2-one 
• 98376-36-4 (R)-2-[(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-propionic acid methyl ester 
• 98376-36-4 2-[(2S,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-propionic acid methyl ester 
• 98376-25-1 [(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-acetic acid methyl ester 
• 98376-30-8 (3-Oxo-propyl)-carbamic acid 4-nitro-benzyl ester 
• 83654-96-0 p-nitrobenzyl glyoxylate monohydrate 
• 98376-39-7 {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-(R)-1-methyl-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 98376-38-6 {(E)-(S)-6-[(2R,3R)-3-(1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-5-oxo-hept-3-enyl}-carbamic acid 4-nitro-benzyl ester 
• 98376-37-5 (3R,4R)-3-(1-Fluoro-ethyl)-4-[(S)-1-methyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-azetidin-2-one 
• 98376-39-7 {(2R,3R)-3-(1-Fluoro-ethyl)-2-[(E)-(S)-1-methyl-6-(4-nitro-benzyloxycarbonylamino)-2-oxo-hex-3-enyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF 3-AMINOALKYL SUBSTITUTED CARBAPENEMS VIA A PHOSPHORANE INTERMEDIATE

Reaction of azetidinone phosphoranes 1 with aldehyde 8 gave the olefins 4, which were converted into carbapenem esters 6 in 4 steps.Hydrogenation of 6 gave the title compounds.