98446-54-9Relevant academic research and scientific papers
A kind of deuterium generation 3-cyano-quinoline compound, a pharmaceutically acceptable composition, preparation method and its use
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Paragraph 0189; 0190, (2016/10/17)
Disclosed in the invention are a deuterated 3-cyano quinoline compound or pharmaceutically acceptable salts, solvates, prodrugs, stereoisomers, tautomers, polymorphic substances, metabolites etc., and a pharmaceutical composition containing such compounds, and the use of these compounds or compositions in the preparation of drugs for treating or preventing tumours, especially drugs such as protein kinase inhibitors. Compared with the prior art, the compounds of the present invention have the clear advantages of properties such as plasma drug concentration, half-life, clearance, microsomal stability, bioavailability or enzyme inhibition and the like, and thus can more effectively inhibit the activities of more than one protein kinase and/or inhibit the growth of tumuor cells.
Pd(II)-catalyzed bromo- and chlorodecarboxylation of electron-rich arenecarboxylic acids
Peng, Xuefeng,Shao, Xiang-Feng,Liu, Zhong-Quan
supporting information, p. 3079 - 3081 (2013/07/11)
A bromo- and chlorodecarboxylation of various aromatic carboxylic acids catalyzed by Pd(II) has been developed in this work. A series of electron-rich arenecarboxylic acids gave the corresponding decarboxylative monohalogenation products under the typical reaction conditions.
Process for the Preparation of a Biphenyl-2-Yl carbamic Acid Ester
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Page/Page column 3, (2012/03/10)
A novel process for the preparation of the compound of formula (II): which process comprises reacting a compound of formula (VI): with a compound of formula (IV): in a suitable solvent.
Herbicidal 1-aryl-4-substituted-1,4-dihydro-5H-tetrazol-5-ones and sulfur analogs thereof
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, (2008/06/13)
Herbicidal aryltetrazolinones and thiones of the formula STR1 in which W is oxygen or sulfur; R is alkyl, fluoroalkyl, alkenyl, haloalkenyl, cyanoalkyl, alkylthioalkyl, haloalkoxyalkyl, trifluoromethylthio or alkoxyalkyl; one of X1 and X2 is fluorine, chlorine, or bromine and the other is fluorine, chlorine, bromine, alkyl, nitro or haloalkyl; and Z is a group selected from a variety of substituents including 2-propynyloxy as disclosed and exemplified.
