98454-67-2Relevant academic research and scientific papers
Addition of C-nucleophiles to 5-phenylpyrimidin-2(1H)-ones and 6-phenyl-1,2,4-triazin-3(2H)-one
Egorov, Ilya N.,Tseitler, Tatyana A.,Zyryanov, Grigory V.,Rusinov, Vladimir L.,Chupakhin, Oleg N.
experimental part, p. 312 - 323 (2011/12/15)
Addition reactions of C-nucleophiles to the C=N bond of 5-phenyl- and 1-methyl-5-phenylpyrimidin-2(1H)-ones 1a,b and 6-phenyl-1,2,4-triazin-3(2H)-one 2 were investigated. 1a,b and 2 furnished addition products with indoles; 1a also added N-methylpyrrole. Only 2 added thiophene and methyl ketones, and reacted with alkyl halides and acetone forming products resulting both from alkylation and from addition of acetone at positions 2 and 5, respectively.
1,2,4-Triazin-3(2H)-ones in Covalent Adduct Formations
Rasmussen, Asbjoern,Rise, Frode,Undheim, Kjell
, p. 235 - 240 (2007/10/02)
The ?-electron deficient 1,2,4-triazin-3(2H)-one system can be compared to carbonyl compounds in many of its reactions.In ethanol or acetone an ethoxy or acetonyl group was added at C(5) in 6-phenyl derivatives.The 5-phenyl isomers were less reactive but
