98489-36-2

Usage

Uses

Used in Pharmaceutical Production:
Pyridine, 5-(aminomethyl)-2,4-dimethyl(6CI) is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of complex organic compounds.
Used in Agrochemical Production:
Pyridine, 5-(aminomethyl)-2,4-dimethyl(6CI) is also utilized as a building block in the creation of agrochemicals, playing a role in the formulation of various agricultural products.
Used in Specialty Chemicals Production:
Pyridine, 5-(aminomethyl)-2,4-dimethyl(6CI) is employed in the production of specialty chemicals, where its unique structure allows for the synthesis of specific compounds for targeted applications.
Safety Measures:
Due to its potential toxicity and hazardous nature, Pyridine, 5-(aminomethyl)-2,4-dimethyl(6CI) must be handled and stored with appropriate safety measures to ensure proper usage and minimize risks.

Upstream product

• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 18872-63-4 6-methyl-4-methoxymethyl-3-cyano-2-chloropyridine 
• 72456-86-1 S-methyl-4,6-dimethyl-2-thiopyridine-3-carbonitrile 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 6623-21-8 3-cyano-4,6-dimethylpyridine 
• 6290-50-2 1-methoxypentane-2,4-dione 
• 6339-38-4 2-hydroxy-4-methoxymethyl-6-methyl-nicotinonitrile 

Downstream Products

• 490-28-8 pyridine-2,4,5-tricarboxylic acid 
• 1070790-89-4 (2R,3S)-3-(6-((4,6-dimethylpyridin-3-ylmethyl)amino)-9-isopropyl-9H-purin-2-ylamino)pentan-2-ol 

Relevant academic research and scientific papers

PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, and Q are defined herein.

Prokineticin 1 receptor antagonists

The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.

Pyrazole compounds and their use as antidiabetes agents

The present invention provides a pyrazole compound that has liver glycogen phosphorylase inhibitory activity and is useful as a therapeutic or prophylactic agent for diabetes, the pyrazole compound represented by the following general formula (I): wherein Ring Q represents an aryl or heteroaromatic group, R1 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or an azido group, R3 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a halo C1-6 alkyl group, a C1-6 alkoxy group, an azido group, an amino group, an acylamino group or a C1-6 alkylsulfonylamino group, R4 and R5 are identical with or different from each other and represent a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, a C3-8 cycloalkyl group, a substituted or unsubstituted saturated heterocyclic group, a substituted or unsubstituted aryl group, a C7-14 aralkyl group, a heteroaromatic group, or the like, or a pharmacologically acceptable salt thereof.

PROKINETICIN 2 RECEPTOR ANTAGONISTS

The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.

Reductive desulfurization of 3-cyano-2-methylthiopyridines under the action of Raney nickel

The action of Raney nickel on substituted 3-cyano-2-methylthiopyridines was studied. Under conditions of catalytic hydrogenation, the reaction yields a mixture containing the aminosulfide resulting from reduction of the nitrile group with retention of the methylthio group, the nitrile resulting from elimination of the methylthio group, and the amine resulting from both reduction of the nitrile group and elimination of the methylthio group. Treatment of 3-cyano-2-methylthiopyridines with a large amount of Raney nickel under desulfurization conditions induces simultaneous elimination of the methylthio group and reduction of the nitrile group to the aminomethyl group. When reductive desulfurization is carried out in methanol or THF, primary amines are formed, while the reactions in isopropyl or ethyl alcohol give secondary or tertiary amines, which are formed upon alkylation of the amino group with alcohols.