98489-83-9

Upstream product

• 21585-16-0 5-(2-hydroxyethyl)-6-methyl-2-thiouracil 
• 74-88-4 methyl iodide 
• 86351-01-1 2-(2-hydroxy-ethyl)-acetoacetic acid ethyl ester 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 21585-16-0 5-(2-hydroxyethyl)-2-mercapto-6-methyl-4(3H)-pyrimidinone 

Downstream Products

• 74187-94-3 2-Hydrazino-5-(2-hydroxy-ethyl)-6-methyl-3H-pyrimidin-4-one 
• 37944-59-5 2-benzylamino-5-(2-hydroxy-ethyl)-6-methyl-3H-pyrimidin-4-one 
• 178268-48-9 7-(4-Fluoro-phenyl)-4-methyl-2-methylsulfanyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites

The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2 receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The invention relates to novel tetrahydropyridin-4-yl indoles of the formula. and tautomers, stereoisomers, prodrugs, N-oxides, pharmacologically acceptable salts, hydrates and solvates thereof, wherein: R1 is hydrogen, halogen, alkyl(C1-3) or alkoxy(C1-3), CN or CF3, R2 is hydrogen or alkyl(C1-3), R3 is hydrogen or alkyl(C1-3), Z is hydrogen or alkyl(C1-3), alkoxy(C1-3) or alkylthio(C1-3), A is hydrogen or alkyl(C1-3), or A and Z together form a saturated or (partly) unsaturated 5- or 6-membered ring which may be substituted with halogen, alkyl (C1-3) or phenyl, in which ring Z represents carbon, sulfur of nitrogen.

Synthesis and in vitro evaluation of some new pyrimidines and related condensed ring systems as potential anticancer agents

Several new pyrimidines 6-11, 18-20, furo-, thieno-, and pyrrolo[2,3-d]pyrimidines 3, 8, 12, triazolo[4,3-a]pyrimidines 14, 15, 16 and tetrazolo[1,5-a]pyrimidine 17 were prepared from the known intermediate 5-(2-hydroxyethyl)-6-methyl-2-thiouracil (2). Compound 7 (4-chloro-5-(2-chloroethyl)-2-methylthio-6-methyl-pyrimidine) exhibited weak antitumor activity in vitro.

2-aminopyrimidinone derivatives

2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and antihistaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects suffering from diseases and/or disorders associated with the

2-aminopyrimidinone derivatives

2-Amino-pyrimidininone derivatives possessing antihistaminic and serotonin-antagonistic properties. Compositions containing these compounds as the active ingredient and a method of treating subjects from allergic diseases.