98508-66-8Relevant academic research and scientific papers
SYNTHESIS OF 4-CARBOXY-2-THIABICYCLOHEPTAN-6-ONES VIA 3-CARBOXY-2,3-DIHYDROTHIOPHENES: POTENTIAL β-LACTAMASE INHIBITORS
Lange, Gerald,Savard, Marc E.,Viswanatha, Thammaiah,Dmitrienko, Gary I.
, p. 1791 - 1794 (1985)
3-Carboalkoxy-2,3-dihydrothiophenes, available by Birch reduction of thiophene-3-carboxylic acid or more efficiently by deconjugation of 2,5-dihydrothiophene-3-carboxylic acid by reaction with ethyl chloroformate and triethylamine, undergo cycloaddition reactions with dichloroketene leading to 4-carboxy-7,7-dichloro-2-thiabicycloheptan-6-ones which are of interest as potential β-lactamase inhibitors.
