Tetrahedron Letters p. 1791 - 1794 (1985)
Update date:2022-08-03
Topics:
Lange, Gerald
Savard, Marc E.
Viswanatha, Thammaiah
Dmitrienko, Gary I.
3-Carboalkoxy-2,3-dihydrothiophenes, available by Birch reduction of thiophene-3-carboxylic acid or more efficiently by deconjugation of 2,5-dihydrothiophene-3-carboxylic acid by reaction with ethyl chloroformate and triethylamine, undergo cycloaddition reactions with dichloroketene leading to 4-carboxy-7,7-dichloro-2-thiabicyclo<3.2.0>heptan-6-ones which are of interest as potential β-lactamase inhibitors.
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Doi:10.1016/S0040-4020(01)96520-2
(1985)Doi:10.1021/acs.orglett.1c02035
(2021)Doi:10.1002/hlca.19540370720
(1954)Doi:10.1016/0008-6215(89)85126-2
(1989)Doi:10.1039/b504128g
(2005)Doi:10.1002/ardp.19853180804
(1985)
