98516-09-7Relevant academic research and scientific papers
Preparations of Chiral Hydroxyester Synthons via Stereoselective Porcine Pancreatic Lipase-catalysed Hydrolyses of meso-Diesters
Kasel, Wolfgang,Hultin, Philip G.,Jones, J. Bryan
, p. 1563 - 1564 (1985)
Stereoselective porcine pancreatic lipase-catalysed hydrolyses of monocyclic meso-1,2-diesters provides a flexible and convenient preparative route to chiral hydroxyesters and lactones of asymmetric synthetic value.
Regio- and stereoselective transacylation of polyhydric alcohols using pronase in organic solvents
Bhattacharya, A,Ali, E
, p. 898 - 899 (2007/10/02)
Pronase a mixture of proteases from Streptomyces griseus has been found to be a good catalyst for transacylation in organic solvents.With equimolar concentrations of p-nitrophenyl acetate as acyl donor in pyridine, aliphatic diols give predominantly the monoacetates.Glucose and isomeric hexoses give the 6-O-acetates in good yield. 6-Deoxy-sugars however, yield mixtures of acetates indicating that regioselectivity among the secondary hydroxyl groups are poor.Racemic trans-1,2-cyclohexanediol affords the (1R, 2R)-monoacetate in 44percent yield with greater than 90percent enantiomer ic purity. cis-1,2-cyclohexanediol and cis-1,2-cyclohexanedimethanol also give optically active monoacetates.
