98534-76-0

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE is used as an intermediate in the synthesis of various pharmaceuticals due to its chemical properties and reactivity, contributing to the development of new drugs.
Used in Agrochemical Industry:
ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE is used as an intermediate in the production of agrochemicals, specifically in the development of pesticides and fungicides, owing to its insecticidal and herbicidal properties.
Used in Chemical Industry:
ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE is utilized in the chemical industry for its potential antifungal and antibacterial activities, indicating its broad-spectrum applications in various chemical processes and formulations.

InChI:InChI=1/C12H11ClN2O2/c1-2-17-12(16)10-8-14-15(11(10)13)9-6-4-3-5-7-9/h3-8H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 54367-64-5 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 4949-44-4 ethyl propanoylacetate 
• 89193-23-7 2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 98476-09-6 5-cyano-1-phenyl-1H-pyrazole-4-carboxylic acid,ethyl ester 
• 98477-03-3 5-cyano-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide 
• 98533-21-2 5-chloro-1-phenyl-N-methyl-1H-pyrazole-4-carboxamide 
• 54367-64-5 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 117766-90-2 1-phenylpyrrolo<3,4-c>pyrazole-4,6(1H,5H)-dione 
• 117766-99-1 (5-cyano-1-phenyl-1H-pyrazole-4-yl)carbamic acid, 1,1-dimethylethyl ester 
• 117766-97-9 5-cyano-1-phenyl-1H-pyrazole-4-carbonyl azide 
• 117766-95-7 4-cyano-N-methyl-1-phenyl-1H-pyrazole-5-carboxamide 
• 117766-94-6 4-cyano-1-phenyl-1H-pyrazole-5-carboxylic acid, methyl ester 
• 117766-91-3 4-(aminocarbonyl)-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 103053-10-7 5-(aminocarbonyl)-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 117766-93-5 4-cyano-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 117766-92-4 4-Cyano-2-phenyl-2H-pyrazole-3-carbonyl chloride 
• 117766-98-0 5-Cyano-1-phenyl-1H-pyrazole-4-carbonyl chloride 

Relevant academic research and scientific papers

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c] dipyrazol-4(7H)-ones and thiones: Synthesis and NMR data

The synthesis of the title compounds is described. Reaction of 1-substituted 2-pyrazolin-5-ones with 5-chloro-1-phenyl-1H-pyrazole-4-carbonyl chloride or 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl chloride, respectively, using calcium hydroxide in refluxing 1,4-dioxane gave the corresponding 4-heteroaroylpyrazol-5-ols, which were cyclized into 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones by treatment with K 2CO3/DMF. The latter were converted into the corresponding thiones upon reaction with Lawesson's reagent. Detailed NMR spectroscopic investigations (1H, 13C, 15N) of the ring systems and their precursors are presented.

Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

Nonaqueous Diazotation of 5-Amino-1-aryl-1H-pyrazole-4-carboxylate Esters

5-Amino-1-aryl-1H-pyrazole-4-carboxylate esters are converted to the corresponding desamino, chloro, bromo, iodo, and methylthio esters by processes involving nonaqueous diazotation.Diazotizing agents are alkyl nitrites except in the case of chlorine wher