98534-80-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID is used as an intermediate in the synthesis of active pharmaceutical ingredients. Its chemical structure makes it a valuable component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID is utilized as an intermediate for the synthesis of agrochemicals. Its properties are harnessed to create compounds that can be used in pest control and crop protection, thereby supporting agricultural productivity.
Used in Materials Science:
2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID is employed in the field of materials science for the development of new materials and compounds. Its unique structure and properties allow researchers to explore its potential in creating innovative materials with specific characteristics for various applications.
Overall, 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID is a versatile chemical compound with significant applications in multiple industries, making it an essential component in the synthesis of various products and contributing to the progress of scientific research and development.

InChI:InChI=1/C11H7F3N2O2/c12-11(13,14)9-8(10(17)18)6-15-16(9)7-4-2-1-3-5-7/h1-6H,(H,17,18)

Upstream product

• 112055-36-4 1-(4-Chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 142503-29-5 3-dimethylaminomethylene-1,1,1,5,5,5-hexafluoropentane-2,4-dione 

Downstream Products

• 1292281-84-5 C₃₀H₂₅ClF₃N₇O₃ 
• 1083418-31-8 1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 175137-19-6 1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride 
• 98534-25-9 1-(4-chlorophenyl)-N-methyl-5-(trifluoromethyl)-1H-4-carboxamide 

Relevant academic research and scientific papers

Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1 H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors

A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed and synthesized a novel se

Discovery and optimization of pyrazole amides as antagonists of CCR1

A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on a pyrazole core motif is presented. Optimization led to the advanced ca

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

Pyrazole-amides and sulfonamides as sodium channel modulators

Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

Pyrazole-amides and sulfonamides as sodium channel modulators

Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

Synthesis of 1-Aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acids and Esters

Ethyl 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylates 2 were prepared by the condensation of arylhydrazines with ethyl 3-ethoxy-2-(trifluoroacetyl)-2-propenoate (1a) at low temperature.The corresponding acids were also synthesized.X-ray diffraction analysis of an amide derivative 4 verified the position of the trifluoromethyl group on the pyrazole ring.