98534-85-1

Usage

Molecular structure

The compound has a pyrazole core and trifluoromethyl substituents.

Molecular weight

390.25 g/mol

Potential applications

The compound has potential applications in medicinal chemistry, particularly as a building block for the synthesis of pharmaceuticals.

Trifluoromethyl groups

The presence of trifluoromethyl groups enhances the biological activity and metabolic stability of drug molecules, making 1H-Pyrazole-4-carboxylic acid, 5-(trifluoromethyl)-1-[3-(trifluoromethyl)phenyl]- potentially useful in drug design.

Importance in drug development

The compound has the potential to be an important building block in the development of new pharmaceuticals and bioactive molecules.

Upstream product

• 3107-33-3 3-(trifluoromethyl)phenylhydrazine hydrochloride 
• 112055-37-5 5-Trifluoromethyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS

Disclosed are compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is formula (II) Q is a substituted 5-membered monocyclic heteroaryl group; W is CH2, O, or NH; and R1, R2, R3, R4, R5, R6, m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Synthesis of 1-Aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acids and Esters

Ethyl 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylates 2 were prepared by the condensation of arylhydrazines with ethyl 3-ethoxy-2-(trifluoroacetyl)-2-propenoate (1a) at low temperature.The corresponding acids were also synthesized.X-ray diffraction analysis of an amide derivative 4 verified the position of the trifluoromethyl group on the pyrazole ring.