3107-33-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(Trifluoromethyl)phenylhydrazine hydrochloride is used as a synthetic intermediate for the development of pharmaceutical compounds. Its role in the synthesis process is crucial for creating inhibitors and anticancer agents that can potentially help in the treatment of various diseases.
Used in Anticancer Applications:
In the field of oncology, 3-(Trifluoromethyl)phenylhydrazine hydrochloride is utilized in the synthesis of isosteviol-fused pyrazolines and pyrazoles, which are considered potential anticancer agents. These compounds may contribute to the advancement of cancer treatment options by targeting specific cancer cell mechanisms and inhibiting their growth.
Used in Chemical Research:
3-(Trifluoromethyl)phenylhydrazine hydrochloride also finds application in chemical research, where it can be employed to study the properties and reactions of trifluoromethyl-containing compounds. This can lead to a better understanding of the behavior of such compounds and their potential applications in various fields, including material science and pharmaceuticals.

InChI:InChI=1/C7H7F3N2/c8-7(9,10)5-2-1-3-6(4-5)12-11/h1-4,12H,11H2

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Downstream Products

• 112055-37-5 5-Trifluoromethyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 66000-40-6 3-amino-1-<3-(trifluoromethyl)phenyl>-2-pyrazoline 
• 64123-94-0 1-methyl-2,4-bis-(3-trifluoromethyl-phenyl)-1,2-dihydro-pyrazol-3-one 
• 1203608-51-8 5-(2-bromo-4-fluorophenyl)-1-(3-trifluoromethylphenyl)pyrazole 
• 1203661-45-3 1-(3-trifluoromethylphenyl)-1,5,6,7-tetrahydroindazol-4-one 
• 321-05-1 5-methyl-2-[3-(trifluoromethyl)phenyl]-2,4-dihydropyrazol-3-one 

Relevant academic research and scientific papers

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

Synthesis, fungicidal activity, structure-activity relationship and density functional theory studies of novel oxime ether derivatives containing 1-aryl-3-oxypyrazoles

A series of 16 oxime ether derivatives containing 1-aryl-3-oxypyrazoles were synthesised, and the structure of one of them, (E)-methyl 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate was determined by X-ray diffraction crystallography. Preliminary bioassays indicated that some of these compounds exhibited very good fungicidal activities against Rhizoctonia solani, especially the ester 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate, which displayed greater activity than control compound pyraclostrobin at a dosage of 0.1 μg mL-1. The relationship between structure and fungicidal activity was discussed. Density functional theory studies of the 3-methyl heterocyclic ester and the 4-chorophenyl heterocyclic N-methylamide were carried out and the results discussed in terms of the wide difference in fungicidal activity shown by each compound.

Facile and convenient synthesis of aryl hydrazines via copper-catalyzed C-N cross-coupling of aryl halides and hydrazine hydrate

An efficient and convenient method for the synthesis of aryl hydrazines has been developed via copper-catalyzed cross-coupling of aryl bromides and hydrazine with a readily accessible ligand and water as a solvent. The multigram scale procedure is applicable to aryl bromides bearing both moderately electron-donating and electron-withdrawing substituents in the aromatic nucleus. No column chromatography is required to obtain aryl hydrazine hydrochlorides in good yields.