98540-26-2

Upstream product

• 1798-09-0 m-methoxyphenylacetic acid 
• 100-66-3 methoxybenzene 
• 1019652-03-9 (2S)-2-(2-bromo-5-methoxy-phenyl)-1-(4-methoxy-phenyl)-ethanol 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 144828-84-2 N-methoxy-1′-(3-methoxyphenyl)-N-methylacetamide 
• 79-22-1 methyl chloroformate 
• 117970-24-8 3',4-dimethoxydeoxybenzoin ethylene acetal 

Downstream Products

• 128349-58-6 (+/-)-1-(4-methoxyphenyl)-2-(3-methoxyphenyl)butan-1-one 
• 117970-24-8 3',4-dimethoxydeoxybenzoin ethylene acetal 
• 133683-37-1 (E/Z)-3-(4-hydroxyphenyl)-4-(3-hydroxyphenyl)hex-3-ene 
• 752221-80-0 (E/Z)-3-(4-hydroxyphenyl)-4-(3-hydroxyphenyl)-14-pentylthiotetradec-3-ene 
• 752221-86-6 (E/Z)-3-(4-hydroxyphenyl)-4-(3-hydroxyphenyl)-14-pentylsulfonyltetradec-3-ene 
• 480-47-7 hydrangenol 
• 1019652-05-1 1′-(3-methoxyphenyl)-2′-(4′′-methoxyphenyl)ethan-2′-ol 
• 474527-23-6 2-(3-hydroxy-phenyl)-4-hydroxy-acetophenone 
• 98540-32-0 Acetic acid 3-{1-[1-(4-acetoxy-phenyl)-1-phenyl-meth-(E)-ylidene]-propyl}-phenyl ester 
• 98540-31-9 Acetic acid 3-{1-[1-(4-acetoxy-phenyl)-1-phenyl-meth-(Z)-ylidene]-propyl}-phenyl ester 

Relevant academic research and scientific papers

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.

Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II

Following our studies of the melatoninergic receptors, we have developed new tetrahydronaphthalenic derivatives of melatonin that have been tested as selective melatonin receptors ligands. Regarding the role of the phenyl substituent to obtain selective l

Asymmetric synthesis of corsifuran A by an enantioselective oxazaborolidine reduction

(Chemical Equation Presented) Corsifuran A has been prepared in an enantiomerically pure form for the first time by an asymmetric reduction procedure, allowing confirmation of the absolute stereochemistry of the natural product as (R).

ESTROGEN RECEPTOR MODULATORS

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or preven

Estrogen receptor modulators

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

TOTAL SYNTHESIS OF (+/-)-HYDRANGENOL

The title compound 8 has been synthesized in five steps and in about 33percent overall yield from 3-methoxyphenylacetic acid, 1.Acid 1 was condensed with anisole in polyphosphoric acid to give 3',4-dimethoxydeoxybenzoin, 2, which was converted to the ethylene acetal 3.The latter was metallated with buthyllithium and carbonated giving crude 3',4-dimethoxydeoxybenzoin-2'-carboxylic acid, 4, from which 3,4-dihydro-8-methoxy-3-(4'-methoxyphenyl)isocoumarin, 7, was obtained either by reduction with sodium borohydride and dehydration, or dehydration to 8-methoxy-3-(4'-methoxyphenyl)isocoumarin, 6, and catalytic hydrogenation.Finally, demethylation of 6 to 8 was performed with boron tribromide.