98554-80-4Relevant academic research and scientific papers
Oxidative Coupling of Diazo and NH4I: A Route to Primary Oxamates and α-Ketoamides
Fang, Shangwen,Li, Jingjing,Wan, Xiaobing,Wang, Hanghang,Zhao, Yanwei,Zheng, Yonggao
supporting information, p. 3050 - 3058 (2020/03/23)
A simple and efficient method has been developed for the preparation of primary oxamates and α-ketoamides through the oxidative coupling of diazo compounds and NH4I. Under the optimized reaction conditions, a range of diazoesters and α-diazoketones was explored, and the corresponding products were obtained in moderate to good yields. This protocol is metal-free, is performed under mild conditions, has a wide substrate scope, and offers operational simplicity.
