98559-25-2

Upstream product

• 29474-11-1 (2-methylcyclohex-1-en-1yl)methanol 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 71712-64-6 2-(Diethoxy-phosphoryloxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 25662-38-8 2-methyl-1-cyclohexenecarboxylic acid methyl ester 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 122135-83-5 ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate 
• 104654-69-5 Ethyl 2-methyl-1-cyclohex-1-ene carboxylate 

Downstream Products

• 63704-29-0 1,2-bis-(2-methyl-cyclohex-1-enyl)-ethane 
• 133728-62-8 5(R*)-<(2-methyl-1-cyclohexen-1-yl)-methyl>-3-ethoxy-2-isopropyl-5-methyl-2-cyclopenten-1-one 
• 129548-21-6 4(R*)-<(2-methyl-1-cyclohexen-1-yl)methyl>-2-isopropyl-4-methyl-3-vinyl-2-cyclopenten-1-one 
• 52329-96-1 1-methyl-2-((phenylcarbonyl)methyl)-1-cyclohexene 

Relevant academic research and scientific papers

PhI(OAc)2-mediated alkoxyoxygenation of β,γ-unsaturated ketoximes: Preparation of isoxazolines bearing two contiguous tetrasubstituted carbons

A PhI(OAc)2-promoted dioxygenation of allyl oximes, including one alkoxylation, has been developed. This reaction can give isoxazoline products bearing two contiguous tetrasubstituted carbons. Various oximes substrates bearing different aryl groups and tetrasubstituted-olefin moieties were compatible with the mild reaction conditions. A two-electron oxidation pathway was proposed based on results of preliminary mechanistic studies.

Asymmetric Aza-Wacker-Type Cyclization of N-Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters

We have developed an asymmetric aza-Wacker-type cyclization of N-Ts hydrazine-tethered tetrasubstituted olefins, affording optically active pyrazolines bearing chiral tetrasubstituted carbon stereocenters. This reaction is tolerant to a broad range of substrates under mild reaction conditions, giving the desired chiral products with high enantioselectivities. Generation of two vicinal stereocenters on the C=C double bonds was also achieved with high selectivities, a process which has been rarely studied for Wacker-type reactions. A mechanistic study revealed that this aza-Wacker-type cyclization undergoes a syn-aminopalladation process. It was also found that for substrates bearing two linear alkyl substituents on the outer carbon atom of the olefin, both of which are larger than a methyl group, the alkyl substituent that is cis to the intranucleophilic group participates more readily in β-hydride elimination. When one of the two alkyl substituents on the outer carbon atom of the olefin is a methyl group, β-hydride elimination proceeds selectively at the methylene side, thus both diastereomers can be prepared via switching the configuration of the olefin. Furthermore, the product can be converted to a pharmaceutical compound in high yields over three steps.

SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS

The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.