122135-83-5

Usage

Uses

Used in Organic Synthesis:
ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE is used as a building block in organic synthesis for its ability to contribute to the formation of complex organic molecules. Its trifluoromethyl sulfonyloxy group and cyclohexene carboxylate moiety provide opportunities for various chemical reactions, enabling the synthesis of a diverse array of compounds with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE is used as a key intermediate in the synthesis of drug molecules. Its unique functional groups can be utilized to create novel pharmaceutical compounds with potential therapeutic properties, contributing to the development of new treatments for various diseases and medical conditions.
Used in Agrochemical Industry:
ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE is also used in the agrochemical industry as a precursor for the development of new pesticides and herbicides. Its chemical properties allow for the creation of compounds with effective pesticidal or herbicidal activity, helping to improve crop protection and yield.
Used in Material Science:
In the field of material science, ETHYL 2-(TRIFLUOROMETHYL SULFONYLOXY)-1-CYCLOHEXENE-1-CARBOXYLATE is used as a component in the synthesis of advanced materials. Its incorporation into polymers and other materials can lead to the development of new materials with improved properties, such as enhanced stability, durability, or specific functional characteristics.

InChI:InChI=1/C10H13F3O5S/c1-2-17-9(14)7-5-3-4-6-8(7)18-19(15,16)10(11,12)13/h2-6H2,1H3

Upstream product

• 456-64-4 phenyl trifluoromethanesulfonamide 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 4840-68-0 2-hydroxy-1-cyclohexenecarboxylic acid ethyl ester 
• 145100-51-2 N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 65136-45-0 2-ethyl-1-methyl-1H-indole 
• 155592-27-1 2-Carbethoxyclohexen-1-yl 1-methylindol-2-yl ketone 
• 122135-88-0 2-(2-phenylethynyl)cyclohexenecarboxylic acid ethyl ester 
• 138616-33-8 ethyl 2-allylcyclohexene-1-carboxylate 
• 173277-75-3 ethyl 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate 
• 179538-88-6 2-(3,5,5,8,8-pentamethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)-1-cyclohexene-1-carboxylic acid ethyl ester 
• 251636-98-3 ethyl 2-but-3-enylcyclohexenecarboxylate 
• 301823-93-8 (+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one 
• 654075-23-7 ethyl 2',5'-dimethoxy-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate 
• 880152-29-4 4-[2-(2-ethoxycarbonyl-cyclohex-1-enyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 174676-17-6 ethyl 2-(trimethylstannyl)-1-cyclohexenecarboxylate 
• 1052737-77-5 ethyl 2-phenylsulfanyl-cyclohex-1-enecarboxylate 
• 1052737-78-6 ethyl 2-iso-propylsulfanyl-cyclohex-1-enecarboxylate 
• 1154051-44-1 2-(2-methyl-1-vinyl-propenyl)-cyclohex-1-enecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Iodane-Guided ortho C?H Allylation

A metal-free C?H allylation strategy is described to access diverse functionalized ortho-allyl-iodoarenes. The method employs hypervalent (diacetoxy)iodoarenes and proceeds through the iodane-guided “iodonio-Claisen” allyl transfer. The use of allylsilanes bearing electron-withdrawing functional groups unlocks the functionalization of a broad range of substrates, including electron-neutral and electron-poor rings. The resulting ortho-allylated iodoarenes are versatile building blocks, with examples of downstream transformation including a concise synthesis of the experimental antimitotic core of Dosabulin. DFT calculations shed additional light on the reaction mechanism, with notable aspects including the aromatic character of the transition-state structure for the [3,3] sigmatropic rearrangement, as well as the highly stereoconvergent nature of the trans-product formation.

Cut and sew: Benzofuran-ring-opening enabled cyclopentenone ring formation

A facile approach to the fully substituted cyclopentenones involving an unprecedented benzofuran-ring-opening is described. The cleavage of a benzofuran endocyclic C2-O bond proceeded smoothly in the absence of any transition metal catalyst or highly reactive organometallic reagent. Such benzofuran-ring-opening is delicately incorporated into an acid-catalyzed cascade process, orchestrating a novel synthetic strategy for complex cyclopentenones with excellent yields and diastereoselectivities. This journal is

Intermolecular copper(I) chloride-mediated coupling of alkenyltrialkylstannane functions: A convenient synthesis of conjugated diene systems

A novel copper(I)-mediated coupling of alkenyltrialkylstannane functions is reported. Thus, treatment of the functionalized stannanes 1-11 with 2,5 equivalents of CuCl in N,N-dimethylformamide (DMF) at room temperature provides good-to-excellent yields of

A convenient method for the synthesis of Δ1,6-bicyclo[4.n.0]alken-2-ones

A convenient annulation method for the synthesis of bicyclic enones from cycloalkanones was developed. In the presence of a Pd(0) catalyst, enol triflates derived from ethyl 2-oxocycloalkanecarboxylates were treated with 3-(ethoxycarbonyl)propylzinc iodid

Preparation method of sulfydryl alkenyl ester compound

The invention relates to a preparation method of a sulfydryl alkenyl ester compound, belongs to the field of organic chemical synthesis, and aims to solve the problems of high risk of large-scale production and the like, and the synthesis route provided b

Preparation method 2 - (chlorosulfonyl) cyclohexane -1 - allyl formate derivative

The invention relates to a preparation method of 2 - (chlorosulfonyl) cyclohexane -1 - allyl formate derivative, which comprises the following steps: 1) dissolving the compound of formula III in an organic solvent; and reacting the compound of formula IV

Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy

In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives is described. This method grants facile access to diverse γ-functionalized cyclopentenones and δ-functionalized cycloheptenones. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity. (Figure presented.).

Mechanistic Divergence in the Hydrogenative Synthesis of Furans and Butenolides: Ruthenium Carbenes Formed by gem-Hydrogenation or through Carbophilic Activation of Alkynes

Enynes with a tethered carbonyl substituent are converted into substituted furan derivatives upon hydrogenation using [Cp*RuCl]4 as the catalyst. Paradoxically, this transformation can occur along two distinct pathways, each of which proceeds via discrete pianostool ruthenium carbenes. In the first case, hydrogenation and carbene formation are synchronized (“gem-hydrogenation”), whereas the second pathway comprises carbene formation by carbophilic activation of the triple bond, followed by hydrogenative catalyst recycling. Representative carbene intermediates of either route were characterized by X-ray crystallography; the structural data prove that the attack of the carbonyl group on the electrophilic carbene center follows a Bürgi–Dunitz trajectory.

Controlling the Selectivity Patterns of Au-Catalyzed Cyclization-Migration Reactions

As little as 2 mol % of (XPhos)AuNTf2 catalyzes the transformation of a broad range of o-acetylene-substituted styrenes into 1,2-dihydronaphthalenes. Our data suggests that this transformation occurs via a gold-stabilized cyclopropyl carbinyl cation, which triggers either a [1,2] carboxylate shift or a less favorable [1,2] aryl shift. The relative rates of these migrations can be controlled by the identity of the ligand or by stabilizing the mesomeric cation.

PhI(OAc)2-mediated alkoxyoxygenation of β,γ-unsaturated ketoximes: Preparation of isoxazolines bearing two contiguous tetrasubstituted carbons

A PhI(OAc)2-promoted dioxygenation of allyl oximes, including one alkoxylation, has been developed. This reaction can give isoxazoline products bearing two contiguous tetrasubstituted carbons. Various oximes substrates bearing different aryl groups and tetrasubstituted-olefin moieties were compatible with the mild reaction conditions. A two-electron oxidation pathway was proposed based on results of preliminary mechanistic studies.