98577-44-7

Basic information

• Product Name: 1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE
• Synonyms: Cyclopropane,1,1-dibroMo-2,2-bis(chloroMethyl)-;1,1-DibroMo-2,2-bis(chloroMethyl)cyclopropane 90%, technical grade;1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE;1,1-BIS(CHLOROMETHYL)-2,2-DIBROMOCYCLOPROPANE;AKOS BBS-00001998;1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)-CYCLOP ROPANE, TECH., 90%;2,2-Bis-(chloromethyl)-1,1-dibromocyclopropane;EOS-60772
• CAS NO: 98577-44-7
• Molecular Formula: C₅H₆Br₂Cl₂
• Molecular Weight: 296.82
• EINECS: 1308068-626-2
• Product Categories: Halogenated Hydrocarbons;Organic Building Blocks;Alkyl
• Mol File: 98577-44-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 48-50 °C(lit.)
• Boiling Point: 277.1 °C at 760 mmHg
• Flash Point: 134.5 °C
• Appearance: /
• Density: 2.065±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0078mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE(98577-44-7)
• EPA Substance Registry System: 1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE(98577-44-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 98577-44-7(Hazardous Substances Data)

Usage

Uses

1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane may be used as a starting material in the synthesis of [1.1.1]-propellane and ((3-ethynylbicyclo[1.1.1]pentan-1-yl)ethynyl)trimethylsilane.

General Description

1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane is a halogenated cyclopropane derivative. It has been reported to be synthesized from 3-chloro-2-(chloromethyl)-1-propene. It is formed as an intermediate during the synthesis of [1.1.1]propellane by Szeimies method.

InChI:InChI=1/C5H6Br2Cl2/c6-5(7)1-4(5,2-8)3-9/h1-3H2

Upstream product

• 1871-57-4 2-chloromethyl-3-chloroprop-1-ene 
• 75-25-2 Bromoform 

Downstream Products

• 105542-98-1 1,3-bisiodobicyclo[1.1.1]pentane 
• 136399-10-5 1-iodo-3-methylbicyclo<1.1.1>pentane 
• 102410-96-8 3,3'-diphenyl-1,1'-bi(bicyclo[1.1.1]pentane) 

Relevant articles and documents

Preparation method 1, 1 - dibromo -2, 2 -bis (chloromethyl) cyclopropane

The invention provides a preparation method of 1, 1 - dibromo -2 and 2 -bis (chloromethyl) cyclopropane. , A reaction starting system containing 3 - chlorine -2 - chloromethyl propylene is added, reactants for generating dibromocarbene are added at the same time, and dibromocarbene is generated in real time. , Based on addition reaction of dibromocarbene and 3 - chlorine -2 - chloromethyl propylene, a target product is generated in real time. The method provided by the invention can ensure that the real-time generated dibromocarb and 3 - chlorine -2 - chloromethyl propylene react in time, so that the reaction time is shortened, and the yield is improved. On the other hand, the amount of reactants can be maintained at a lower level to reduce the generation of by-products, increasing the purity. In addition, the method can also avoid massive precipitates in the reaction system, so that the reaction is more sufficient, the reaction time is further shortened, the yield and the purity are improved, the post-treatment difficulty and cost are reduced, and the applicability of industrial production is improved.

CONTINUOUS FLOW PROCESSES FOR MAKING BICYCLIC COMPOUNDS

Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

FUSED FURANS FOR THE TREATMENT OF HEPATITIS C

The disclosure provides compounds of formula I or II, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. [