98593-51-2

Basic information

• Product Name: 4-(Methylsulphonyl)benzylamine hydrochloride
• Synonyms: p-(methylsulfonyl)benzylaminehydrochloride;p-(methylsulfonyl)-benzylaminhydrochloride;p-methylsulphonylbenzylaminehydrochloride;4-METHYLSULPHONYLBENZYLAMINE HYDROCHLORIDE;4-METHYLSULFONYLBENZYLAMINE HYDROCHLORIDE;4-Methanesulfonylbenzylamine hydrochloride;(4-(methylsulfonyl)phenyl)methanamine hydrochloride;4-(methylthio)-1,2-dihydroquinazoline
• CAS NO: 98593-51-2
• Molecular Formula: C₈H₁₁NO₂S*ClH
• Molecular Weight: 221.7
• Mol File: 98593-51-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 272-274
• Boiling Point: 369.9 °C at 760 mmHg
• Flash Point: 177.5 °C
• Appearance: /
• Density: 1.225g/cm3
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(Methylsulphonyl)benzylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Methylsulphonyl)benzylamine hydrochloride(98593-51-2)
• EPA Substance Registry System: 4-(Methylsulphonyl)benzylamine hydrochloride(98593-51-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• Hazardous Substances Data: 98593-51-2(Hazardous Substances Data)

Usage

General Description

4-(Methylsulphonyl)benzylamine hydrochloride is a chemical compound with the molecular formula C8H12ClNO2S. It is a derivative of benzylamine and contains a methylsulphonyl group. 4-(Methylsulphonyl)benzylamine hydrochloride is commonly used in the pharmaceutical industry as a precursor in the synthesis of various pharmacologically active molecules. It is also utilized in research and development for its potential therapeutic applications. The hydrochloride salt form of 4-(Methylsulphonyl)benzylamine is more stable and water-soluble, making it easier to handle and administer in various experimental and manufacturing processes.

InChI:InChI=1/C8H11NO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3

Upstream product

• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 22821-77-8 p-methylsulfonylbenzyl alcohol 

Downstream Products

• 861102-85-4 6-ethyl-5-[4-(4-methanesulfonyl-benzylamino)-3-nitro-phenyl]-pyrimidine-2,4-diamine 
• 694475-15-5 6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1569649-33-7 6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 694480-93-8 6-(isopropyl)-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1612182-30-5 6-(2,3-dimethylphenyl)-4-N-[(4-methanesulfonylphenyl)methyl]pyrimidine-2,4-diamine 
• 1611473-62-1 8-bromo-N-(4-(methylsulfonyl)benzyl)-1,6-naphthyridine-2-carboxamide 
• 1569645-59-5 1-cyclopropyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1571135-40-4 2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid 4-methanesulfonylbenzylamide 
• 1571135-36-8 5-bromo-1-[1-(4-cyanophenyl)ethyl]-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 1571134-67-2 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 1571133-23-7 1-(4-cyanobenzyl)-6-methyl-4-oxo-5-phenyl-1,4-dihydropyridine-3-carboxylic acid 4-(methanesulfonyl)benzylamide 

Relevant articles and documents

Catalytic Staudinger Reduction at Room Temperature

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

A novel efficient and chemoselective method for the reduction of nitriles using the system silane/oxo-rhenium complexes

This work reports the reduction of nitriles to the corresponding primary amines with silanes catalyzed by oxo-rhenium complexes. The catalytic system PhSiH3/ReIO2(PPh3)2 (10 mol %) reduced efficiently a series of nitriles in the presence of a wide range of functional groups such as -Cl, -F, -Br, -I, -CF3, -OCH3, -SCH3, -SO2CH3 and -NHTs.