98593-51-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(Methylsulphonyl)benzylamine hydrochloride is used as a precursor in the synthesis of various pharmacologically active molecules. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic benefits.
Used in Research and Development:
In the realm of scientific research, 4-(Methylsulphonyl)benzylamine hydrochloride is utilized for exploring its potential therapeutic applications. Its properties are studied to understand how it may contribute to the treatment or management of certain diseases or conditions.
The hydrochloride salt form of 4-(Methylsulphonyl)benzylamine enhances the compound's stability and water solubility, which is crucial for its easier handling and administration in experimental and manufacturing processes. This makes it a valuable asset in the development of pharmaceutical formulations and drug delivery systems.

InChI:InChI=1/C8H11NO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3

Upstream product

• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 22821-77-8 p-methylsulfonylbenzyl alcohol 

Downstream Products

• 904311-42-8 4-Amino-6-chloro-5-cyano-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide 
• 694475-15-5 6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1227627-51-1 ethyl 1-methyl-8-([4-(methylsulfonyl)benzyl]-amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate 
• 1571135-33-5 5-bromo-1-(4-cyanobenzyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 1571133-23-7 1-(4-cyanobenzyl)-6-methyl-4-oxo-5-phenyl-1,4-dihydropyridine-3-carboxylic acid 4-(methanesulfonyl)benzylamide 
• 1571134-67-2 1-(4-cyanobenzyl)-4-oxo-5-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 1612182-30-5 6-(2,3-dimethylphenyl)-4-N-[(4-methanesulfonylphenyl)methyl]pyrimidine-2,4-diamine 
• 1611473-62-1 8-bromo-N-(4-(methylsulfonyl)benzyl)-1,6-naphthyridine-2-carboxamide 
• 1569645-59-5 1-cyclopropyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1571135-40-4 2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid 4-methanesulfonylbenzylamide 
• 1571135-36-8 5-bromo-1-[1-(4-cyanophenyl)ethyl]-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide 
• 1569649-33-7 6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1569649-79-1 5-bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide 
• 1300031-19-9 2,6-dimethyl-N-(4-(methylsulfonyl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide 

Relevant academic research and scientific papers

Catalytic Staudinger Reduction at Room Temperature

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

A novel efficient and chemoselective method for the reduction of nitriles using the system silane/oxo-rhenium complexes

This work reports the reduction of nitriles to the corresponding primary amines with silanes catalyzed by oxo-rhenium complexes. The catalytic system PhSiH3/ReIO2(PPh3)2 (10 mol %) reduced efficiently a series of nitriles in the presence of a wide range of functional groups such as -Cl, -F, -Br, -I, -CF3, -OCH3, -SCH3, -SO2CH3 and -NHTs.