861102-85-4Relevant articles and documents
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists
Xin, Zhili,Serby, Michael D.,Zhao, Hongyu,Kosogof, Christi,Szczepankiewicz, Bruce G.,Liu, Mei,Liu, Bo,Hutchins, Charles W.,Sarris, Kathy A.,Hoff, Ethan D.,Falls, H. Douglas,Lin, Chun W.,Ogiela, Christopher A.,Collins, Christine A.,Brune, Michael E.,Bush, Eugene N.,Droz, Brian A.,Fey, Thomas A.,Knourek-Segel, Victoria E.,Shapiro, Robin,Jacobson, Peer B.,Beno, David W. A.,Turner, Teresa M.,Sham, Hing L.,Liu, Gang
, p. 4459 - 4469 (2006)
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have