98594-61-7Relevant academic research and scientific papers
Isatin: A privileged scaffold for the design of carbonic anhydrase inhibitors
Melis, Claudia,Meleddu, Rita,Distinto, Simona,Bianco, Giulia,Cottiglia, Filippo,Maccioni, Elias,Angeli, Andrea,Supuran, Claudiu T.,Capasso, Clemente,Angius, Rossella
, p. 68 - 73 (2017)
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been
Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
Distinto, Simona,Meleddu, Rita,Ortuso, Francesco,Cottiglia, Filippo,Deplano, Serenella,Sequeira, Lisa,Melis, Claudia,Fois, Benedetta,Angeli, Andrea,Capasso, Clemente,Angius, Rossella,Alcaro, Stefano,Supuran, Claudiu T.,Maccioni, Elias
, p. 1526 - 1533 (2019)
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitory poten
