98601-72-0

Upstream product

• 36692-27-0 2-chlorophenylmagnesium bromide 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 14313-60-1 6-chlorobenzo[c]isoxazole? 
• 694-80-4 2-bromo-1-chlorobenzene 
• 214971-18-3 4-chloroanthranilic acid N-methoxy-N-methylamide 

Downstream Products

• 152911-53-0 (2-amino-4-chloro-phenyl)-(2-chloro-phenyl)-methanol 
• 152911-70-1 [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol 
• 152911-92-7 (E)-3-[{5-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Organocatalytic Atroposelective Friedl?nder Quinoline Heteroannulation

An atroposelective Friedl?nder heteroannulation reaction of 2-aminoaryl ketones with α-methylene carbonyl derivatives has been developed for the first time with chiral phosphoric acid as an efficient organocatalyst. The desired enantioenriched axially chi

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities

A series of (3,5-trans)-2-oxo-5-phenyl-1,2,3,5-tetrahydro-4,1-benzoxazepine derivatives were synthesized and evaluated for squalene synthase inhibitory and cholesterol biosynthesis inhibitory activities. Through modification of substituents of the lead compounds 1a and 1b, it was found that 4,1-benzoxazepine-3-acetic acid derivatives with isobutyl and neopentyl groups at the 1-position, the chloro atom at the 7-position, and the chloro and methoxy groups at the 2'-position on the 5-phenyl ring, had potent squalene synthase inhibitory activity. Among such compounds, the 5-(2,3-dimethoxyphenyl) derivative 2t exhibited potent inhibition of cholesterol biosynthesis in HepG2 cells. As a result of optical resolution study of 2t, the absolute stereochemistry required for inibitory activity was determined to be 3R,5S. In vivo study showed that the sodium salt of (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-aceitc acid 20 effectively reduced plasma cholesterol in marmosets. Copyright