152911-70-1

Basic information

• Product Name: [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol
• Synonyms: [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol
• CAS NO: 152911-70-1
• Molecular Weight: 338.277
• Mol File: 152911-70-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol(152911-70-1)
• EPA Substance Registry System: [4-chloro-2-(2,2-dimethyl-propylamino)-phenyl]-(2-chloro-phenyl)-methanol(152911-70-1)

Safety Data

• Hazardous Substances Data: 152911-70-1(Hazardous Substances Data)

Upstream product

• 630-19-3 pivalaldehyde 
• 152911-53-0 (2-amino-4-chloro-phenyl)-(2-chloro-phenyl)-methanol 
• 98601-72-0 (2-amino-4-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 36692-27-0 2-chlorophenylmagnesium bromide 

Downstream Products

• 152911-92-7 (E)-3-[{5-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester 

Relevant articles and documents

Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities

A series of (3,5-trans)-2-oxo-5-phenyl-1,2,3,5-tetrahydro-4,1-benzoxazepine derivatives were synthesized and evaluated for squalene synthase inhibitory and cholesterol biosynthesis inhibitory activities. Through modification of substituents of the lead compounds 1a and 1b, it was found that 4,1-benzoxazepine-3-acetic acid derivatives with isobutyl and neopentyl groups at the 1-position, the chloro atom at the 7-position, and the chloro and methoxy groups at the 2'-position on the 5-phenyl ring, had potent squalene synthase inhibitory activity. Among such compounds, the 5-(2,3-dimethoxyphenyl) derivative 2t exhibited potent inhibition of cholesterol biosynthesis in HepG2 cells. As a result of optical resolution study of 2t, the absolute stereochemistry required for inibitory activity was determined to be 3R,5S. In vivo study showed that the sodium salt of (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-aceitc acid 20 effectively reduced plasma cholesterol in marmosets. Copyright