98631-95-9 Usage
Description
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in
Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma
(ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane
exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing
topoisomerase II inhibitor and exerts its function via interfering with the
catalytic activity of the enzyme to result in an irreversible inhibition of cell division by
blockade of chromosome condensation and segregation. Due to Its unique mode of
cytocidai activity, it has no cross resistance with many currently available
anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human
colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Originator
Zenyaku Kogyo (Japan)
Uses
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
Brand name
Perazolln
Check Digit Verification of cas no
The CAS Registry Mumber 98631-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,6,3 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 98631-95:
(7*9)+(6*8)+(5*6)+(4*3)+(3*1)+(2*9)+(1*5)=179
179 % 10 = 9
So 98631-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H34N4O10/c1-15(2)11-33-21(31)35-13-25-17(27)7-23(8-18(25)28)5-6-24-9-19(29)26(20(30)10-24)14-36-22(32)34-12-16(3)4/h15-16H,5-14H2,1-4H3
