98655-52-8Relevant academic research and scientific papers
Di-tert-butylneopentylphosphine (DTBNpP): An Efficient Ligand in the Palladium-Catalyzed α-Arylation of Ketones
Raders, Steven M.,Jones, Jessica M.,Semmes, Jeffrey G.,Kelley, Steven P.,Rogers, Robin D.,Shaughnessy, Kevin H.
, p. 7395 - 7404 (2016/02/19)
Di-tert-butylneopentylphosphine (DTBNpP) and palladium(II) acetate provide an efficient catalytic system for the α-arylation of ketones. Aryl bromides were coupled with ketones using 0.25-0.5 mol-% Pd(OAc)2/DTBNpP in toluene at 50 C, whereas aryl chlorides required a higher catalyst loading (0.5-2.0 mol-%) and a higher temperature (80 C). Coupling of 2-bromophenol with ketones using the Pd/DTBNpP system provides an efficient route for the synthesis of benzofurans.
One-pot synthesis of benzofurans via palladium-catalyzed enolate arylation with o-bromophenols
Eidamshaus, Christian,Burch, Jason D.
supporting information; experimental part, p. 4211 - 4214 (2009/06/06)
(Chemical Equation Presented) A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation is described. The process demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate to excelle
New synthesis of 2-aryl-3-substituted benzo[b]furans from benzyl 2-halophenyl ethers
Sanz, Roberto,Miguel, Delia,Martinez, Alberto,Perez, Antonio
, p. 4024 - 4027 (2007/10/03)
Treatment of benzyl 2-halophenyl ethers with 3 equiv of t-BuLi results in Li-halogen exchange and lithiation at benzylic methylene simultaneously. These dianions do not undergo Wittig rearrangement and can be trapped with electrophiles. Their reactions with carboxylic esters afford the corresponding 2-aryl-3-hydroxy-2,3-dihydrobenzo[b]-furans as a mixture of diastereoisomers. Subsequent acid-catalyzed or mediated dehydration gives moderate to good overall yield of a variety of 2-aryl-3-substituted benzo[fe]-furans.
