98664-62-1Relevant academic research and scientific papers
Simultaneous dehalogenation and hydrogenation reduction of halogen-heteroaromatic aldehydes
Chen, Xi-Bo,Hu, Qiu-Peng,Yuan, Qian-Jia,Ding, Wei,Ren, Jiangmeng,Zeng, Bu-Bing
experimental part, p. 3798 - 3801 (2012/09/21)
Treatment of halogen-heteroaromatic aldehydes with catalytic amount of PdCl2 under atmosphere pressure of hydrogen in base medium (sodium acetate) leads to the corresponding dehalogenated primary alcohols. The reaction system was especially effective for the heteroaromatic compounds bearing aldehyde groups and halides (bromo- or chloro-functions).
METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS
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Page/Page column 208, (2010/12/18)
The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.
COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
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Page/Page column 61-62, (2008/06/13)
The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.
13C NMR SPECTRAL AND STEREOCHEMICAL ANALYSIS OF PIPERIDINE DERIVED α-AMINONITRILES
Jokela, Reija,Tamminen, Tarja,Lounasmaa, Mauri
, p. 1707 - 1722 (2007/10/02)
Carbon-13 NMR spectra of several α-aminonitriles are reported, along with their preparation via the modified Polonovski reaction or the reductive cyanation of Fry.The substituent effects for the cyano group in the different nitrogen heterocycles were dete
