98677-37-3

Basic information

• Product Name: Trandolapril Benzyl Ester
• Synonyms: Trandolapril Benzyl Ester
• CAS NO: 98677-37-3
• Molecular Formula: C₃₁H₄₀N₂O₅
• Molecular Weight: 520.6597
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 98677-37-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate
• CAS DataBase Reference: Trandolapril Benzyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Trandolapril Benzyl Ester(98677-37-3)
• EPA Substance Registry System: Trandolapril Benzyl Ester(98677-37-3)

Safety Data

• Hazardous Substances Data: 98677-37-3(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

Protected Trandolapril (T713500), an antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.

Upstream product

• 144540-71-6 (2S,3aR,7aS-octahydroindole)-2-carboxylic acid-benzyl ester 
• 80828-26-8 N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride 
• 114192-42-6 N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride 
• 145641-35-6 phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride 
• 84793-24-8 N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride 
• 82717-90-6 benzyl (2SR,3aRS,7aSR)-octahydro-1H-indole-2-carboxylate 
• 82717-90-6 cis,syn-octahydro-1H-indole-2(S)-carboxylic acid, phenylmethylester 
• 82717-96-2 [1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine 

Downstream Products

• 87679-37-6 trandolapril 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF AMIDES OF N-[1-(S)-(ETHOXYCARBONYL)-3-PHENYLPROPYL]-L-ALANINE

A process for the production of amides of N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine is described. The process can be used for the production of key intermediates and finally the ACE inhibitors such as Ramipril, Enalapril, Quinapril, Trandolapril, Delapril and Moexipril starting from N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine by the reaction with the appropriate amines.

A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE

A method for the synthesis of a compound of formula (I) as a mixture of enantiomers, formula (I) (wherein R1 is H or an acid protective group and H+A- indicates an optional acid with which the compound of formula (I) may form an ammonium salt) said method comprising; A) reacting a cyclohexyl aziridine with a dialkyl malonate, whereby to provide a trans-fused 3-alkylcarbonyl-octahydro-indol-2-one; B) decarbonylation at the 3-position, conversion of the ketone of the resulting trans-octahydro-indol-2-one to an optionally protected carboxylic acid group; and C) optionally removing any N-substitution if necessary.