98684-22-1Relevant academic research and scientific papers
RENIN INHIBITORS
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, (2008/06/13)
Renin inhibiting compounds of the formula: STR1 containing two . alpha.-amino acids or a single α-amino acid wherein R 1 is a phosphorus containing moiety, W is oxygen or NR 3 and A is a moiety selected from those of the formula: STR2 wherein Z is O, S, SO, SO. sub.2 and p is an integer from 1 to 2; and, when W is oxygen, A may also be a moiety of the formula STR3 and analogs thereof which compounds inhibit the substrate-cleaving action of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.
NEIGHBOURING GROUP PARTICIPATION IN PHOSPHATE ESTERS. FRAGMENTATION OF PHOSPHOROCHLORIDATES
Cocks, S.,Modro, T. A.
, p. 945 - 948 (2007/10/02)
(β-Arylethyl)phosphorochloridates decompose easily yielding 1-chloro-2-arylethanes and/or arylethylenes, presumably via the concerted P-Cl fission and the expulsion of metaphosphate-like species.
