987-02-0

Usage

Uses

Used in Pharmaceutical Industry:
Demecycline is used as an antibiotic agent for treating bacterial infections. Its antimicrobial properties help in combating a range of bacterial pathogens, providing a therapeutic solution for various infections.
Used in Veterinary Medicine:
In the veterinary field, Demecycline is used as an antimicrobial agent for treating infections in animals. It helps in controlling and preventing the spread of bacterial diseases, ensuring the health and well-being of animals.
Used in Aquaculture:
Demecycline is employed as an antibacterial agent in aquaculture to maintain the health of aquatic organisms. It helps in controlling bacterial infections in fish and other aquatic species, contributing to the overall productivity and sustainability of the industry.
Used in Agricultural Industry:
In agriculture, Demecycline can be used as an antimicrobial agent to protect crops from bacterial infections. Its application helps in maintaining crop health and productivity, ensuring a stable food supply.
Overall, Demecycline's versatile applications in various industries highlight its importance as an antibiotic substance with significant potential in combating bacterial infections and promoting overall health and productivity.

InChI:InChI=1/C21H22N2O8/c1-23(2)14-9-6-8-12(16(26)11-7(15(8)25)4-3-5-10(11)24)18(28)21(9,31)19(29)13(17(14)27)20(22)30/h3-5,8-9,14-15,24-26,30-31H,6,22H2,1-2H3/b20-13-/t8-,9-,14-,15+,21-/m0/s1

Upstream product

• 127-33-3 Demeclocycline 
• 64-73-3 demeclocycline hydrochloride 

Downstream Products

• 10118-90-8 MINOCYCLINE 
• 808-26-4 sancycline 
• 129044-45-7 (4aS)-4t-dimethylamino-3,6t,10,12,12a-pentahydroxy-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide 

Relevant academic research and scientific papers

METHODS FOR ENGINEERING THERAPEUTICS AND USES THEREOF

The disclosed subject matter provides for genetically modified cells, e.g, fungal cells, that autonomously generates and/or secretes one or more therapeutic molecules, e.g, therapeutic peptides, therapeutic proteins or small therapeutic molecules, in situ. In certain embodiments, the present disclosure provides genetically-engineered fungal cells that generate and secrete tetracycline and analogues thereof.

Preparation process of 6-demethyl-6-deoxytetracycline

The invention discloses a preparation process of 6-demethyl-6-deoxytetracycline. The preparation process comprises the following steps: sequentially adding demethylchlortetracycline and urea into softwater, uniformly mixing, reacting in a hydrogen environment by taking Pd/C as a catalyst, filtering the catalyst to obtain a compound I; dissolving the obtained compound I in alcohol, adding an acid,stirring until the compound I is completely dissolved, adding DMF, reacting in a hydrogen environment by taking Pd/C as a catalyst, filtering the catalyst to obtain a compound II; concentrating the compound II under a reduced pressure, recovering alcohol, drying, adding into soft water, adding urea for dissolving, filtering to obtain double salt; adding the double salt into alcohol, stirring for2 hours at a low temperature, and filtering to obtain a high-purity compound II. The preparation process has the beneficial effects that an isomer with a lactone structure is prevented from being generated by ring opening; the yield and the purity are improved; not only is the safety coefficient of production improved, but also the cost loss caused by the loss of an organic solvent is reduced; thereaction temperature is reduced, the product purity is improved; and the epimers are reduced.

Preparation method 6 - demethyl -6 - dewatered tetracycline (by machine translation)

6 - Demethyltetracycline is added into purified water, ammonia water is added dropwise, pH is adjusted to -6 - and then urea and Pd / C catalyst are added dropwise to obtain 6 - 8 demethyl 0.3 - 1.5 mpa-dehydrated tetracycline, and the obtained 6 - demethyl 6 -dehydrated tetracycline can be used as an impurity qualitative and quantitative comparison product in production and can also provide a great sample for the subsequent dehydration of tetracycline hydrochloride to deoxytetracycline in the process of 1 - 3 mpa demethyl-6 -demethylcyclophilins obtained by dropwise addition of urea and a Pd/C catalyst to prepare 6 - 6 - demethyltetracycline, 5a - and removing and generating a double bond by dropwise addition 6 - of urea -6 and a Pd/C catalyst 95percent.6 . (by machine translation)

Preparation method of minocycline hydrochloride

The invention provides a preparation method of minocycline hydrochloride. The preparation method comprises the following steps: 1) preparing sancycline: preparing the sancycline by taking demeclocycline hydrochloride as a raw material; 2) preparing 7-iodosancycline: under a strong acid condition, taking N-iodosuccinimide and the sancycline to react to prepare a reaction solution, namely the 7-iodosancycline; 3) preparing the minocycline hydrochloride: taking the 7-iodosancycline and dimethylaminotrimethyl tin to react in an amine solvent and an amide solvent under the action of a palladium complex catalyst to prepare a reaction solution, and adjusting the pH (Potential of Hydrogen) of the reaction solution to be 0.8 to 1.0 with concentrated hydrochloric acid; after de-coloring with active carbon, adjusting the pH of the reaction solution to be 3.8 to 4.0 with ammonia water; freezing and crystallizing; after filtering, drying a filter cake to obtain the minocycline hydrochloride. The minocycline hydrochloride prepared by the preparation method has the advantages of low cost, stable structure, few isomer impurities, low content of epimers and relatively high product purity.