987-02-0

Basic information

• Product Name: Demecycline
• Synonyms: Demecycline;AIX;Antibiotic RP-6798;CL 22415;Demethyltetracycline;RP-6798;Demeclocycline EP impurity A;Tetracycline 6-demethyl
• CAS NO: 987-02-0
• Molecular Formula: C₂₁H₂₂N₂O₈
• Molecular Weight: 430.411
• Product Categories: Amines, Aromatics, Metabolites & Impurities
• Mol File: 987-02-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 693.5°Cat760mmHg
• Flash Point: 373.2°C
• Appearance: /
• Density: 1.69g/cm³
• Vapor Pressure: 3.43E-20mmHg at 25°C
• Refractive Index: 1.757
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility: Aqueous Acid (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.50±1.00(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: Demecycline(CAS DataBase Reference)
• NIST Chemistry Reference: Demecycline(987-02-0)
• EPA Substance Registry System: Demecycline(987-02-0)

Safety Data

• Hazardous Substances Data: 987-02-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 987-02-0 differently. You can refer to the following data:
1. Demethyltetracycline is a Chlortetracycline(C426500) metabolite, an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.
2. Demethyltetracycline is a Chlortetracycline (C426500) metabolite, an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.

InChI:InChI=1/C21H22N2O8/c1-23(2)14-9-6-8-12(16(26)11-7(15(8)25)4-3-5-10(11)24)18(28)21(9,31)19(29)13(17(14)27)20(22)30/h3-5,8-9,14-15,24-26,30-31H,6,22H2,1-2H3/b20-13-/t8-,9-,14-,15+,21-/m0/s1

Upstream product

• 127-33-3 Demeclocycline 
• 64-73-3 demeclocycline hydrochloride 

Downstream Products

• 10118-90-8 MINOCYCLINE 
• 808-26-4 sancycline 
• 129044-45-7 (4aS)-4t-dimethylamino-3,6t,10,12,12a-pentahydroxy-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide 

Relevant articles and documents

METHODS FOR ENGINEERING THERAPEUTICS AND USES THEREOF

The disclosed subject matter provides for genetically modified cells, e.g, fungal cells, that autonomously generates and/or secretes one or more therapeutic molecules, e.g, therapeutic peptides, therapeutic proteins or small therapeutic molecules, in situ. In certain embodiments, the present disclosure provides genetically-engineered fungal cells that generate and secrete tetracycline and analogues thereof.

Preparation method 6 - demethyl -6 - dewatered tetracycline (by machine translation)

6 - Demethyltetracycline is added into purified water, ammonia water is added dropwise, pH is adjusted to -6 - and then urea and Pd / C catalyst are added dropwise to obtain 6 - 8 demethyl 0.3 - 1.5 mpa-dehydrated tetracycline, and the obtained 6 - demethyl 6 -dehydrated tetracycline can be used as an impurity qualitative and quantitative comparison product in production and can also provide a great sample for the subsequent dehydration of tetracycline hydrochloride to deoxytetracycline in the process of 1 - 3 mpa demethyl-6 -demethylcyclophilins obtained by dropwise addition of urea and a Pd/C catalyst to prepare 6 - 6 - demethyltetracycline, 5a - and removing and generating a double bond by dropwise addition 6 - of urea -6 and a Pd/C catalyst 95percent.6 . (by machine translation)