808-26-4Relevant articles and documents
Preparation process of 6-demethyl-6-deoxytetracycline
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Paragraph 0037; 0045; 0047-0049; 0051-0053; 0055-0057; 0059, (2020/07/15)
The invention discloses a preparation process of 6-demethyl-6-deoxytetracycline. The preparation process comprises the following steps: sequentially adding demethylchlortetracycline and urea into softwater, uniformly mixing, reacting in a hydrogen environment by taking Pd/C as a catalyst, filtering the catalyst to obtain a compound I; dissolving the obtained compound I in alcohol, adding an acid,stirring until the compound I is completely dissolved, adding DMF, reacting in a hydrogen environment by taking Pd/C as a catalyst, filtering the catalyst to obtain a compound II; concentrating the compound II under a reduced pressure, recovering alcohol, drying, adding into soft water, adding urea for dissolving, filtering to obtain double salt; adding the double salt into alcohol, stirring for2 hours at a low temperature, and filtering to obtain a high-purity compound II. The preparation process has the beneficial effects that an isomer with a lactone structure is prevented from being generated by ring opening; the yield and the purity are improved; not only is the safety coefficient of production improved, but also the cost loss caused by the loss of an organic solvent is reduced; thereaction temperature is reduced, the product purity is improved; and the epimers are reduced.
A mountain of tigecycline preparation method
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Paragraph 0031; 0032; 0033; 0034; 0035; 0036-0050, (2017/06/19)
The invention discloses a preparation method for sancycline. The preparation method comprises the step of subjecting a compound I to a reaction in a mixed solvent of alcohol and acid in a hydrogen environment under the action of a catalyst so as to obtain a compound II, wherein the alcohol is C1 to C6 alcohol, and the acid is one selected from the group consisting of sulfuric acid, hydrobromic acid, methanesulfonic acid, p-toluenesulfonic acid, perchloric acid and phosphoric acid with weight percentage of 85%. The preparation method provided by the invention has the advantages of high yield, a few reaction by-products, high purity, simple and convenient process, easy post-treatment, recoverability of the solvent and the catalyst, small environmental protection pressure, low cost and suitability for industrial production.
TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED METHODS OF TREATMENT
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Page/Page column 36, (2010/04/25)
The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.