98700-50-6

Usage

Uses

Used in Pharmaceutical Industry:
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is used as a reactant for the synthesis of (aminomethyl)pyrazoles through reductive amination. These compounds act as Smoothened antagonists, which are important for hair inhibition applications, offering potential treatments for conditions like hirsutism or excessive hair growth.
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is also used as a reactant in the synthesis of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine. These antagonists are significant in the development of drugs targeting the opioid receptor-like 1 (ORL1), which has implications in pain management and other therapeutic areas.
Furthermore, 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE is utilized in the preparation of pharmacologically active dialkylamino(phenyl-1H-pyrazolyl)butanols. These compounds have potential applications in medicine, particularly as they may exhibit biological activities that can be harnessed for therapeutic purposes.

InChI:InChI=1/C11H10N2O/c1-9-10(8-14)7-12-13(9)11-5-3-2-4-6-11/h2-8H,1H3

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 89193-16-8 ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate 
• 100-63-0 phenylhydrazine 
• 153863-35-5 (5-methyl-1-phenyl-1H-pyrazol-4-yl)methanol 
• 98700-49-3 4-(4-Fluorophenylimino)methyl-5-methyl-1-phenyl-1H-pyrazole 
• 3483-16-7 4-methyl-3-phenyl-sydnone 
• 98700-38-0 4-[3-(4-Fluoro-phenyl)-5-methylene-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine 

Downstream Products

• 193747-18-1 (5-Methyl-1-phenyl-1H-pyrazol-4-yl)-phenyl-methanol 
• 1204423-67-5 ethyl 2-fluoro-3-(5-methyl-1-phenylpyrazol-4-yl)acrylate 

Relevant academic research and scientific papers

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND

The present invention provides a compound having excellent regulating action on blood lipid level. The present invention provides a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, etc., wherein A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R1 represents COOH or the like; each R2 represents an alkyl or the like; each R3 represents an optionally substituted phenyl, an optionally substituted phenylalkyl, or the like; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R4, R5, R6, and R7 represents H, an alkyl, or the like; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of B1 and B2 represents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl.

1,6 - SUBSTITUTED (3R,6R) -3- (2,3-DIHYDRO-1H-INDEN-2-YL)-2,5-PIPERAZINEDIONE DERIVATIVES AS OXYTOCIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PRE-TERM LABOUR, DYSMENORRHEA AND ENDOMETRIOSIS

The present invention relates to compound S of Formula (I).

ω-Dialkylaminoalkyl Ethers of Phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with Analgesic and Anti-inflammatory Activity

A series of carbinols 3a-f was prepared starting from methanols 1a-f via oxidation with pyridinium chlorochromate to aldehydes 2a-f, followed by a Grignard reaction of the latter. Reaction of 3a-f with ω-chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g-t. Compounds 4i,m-p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,l,s exhibited a moderate anti-inflammatory activity in the carrageenan-induced edema assay in rats.

ν-Triazolines, XXIV-Pyrazolecarbaldehydes from 5-Amino-4,5-dihydro-4-methylene-ν-triazoles and Sydnones

The sydnones 1a-c react with the 4,5-dihydro-ν-triazoles 2a-c by long refluxing at 110-140 deg C affording via non-isolable adducts with elimination of CO2 and N2 and rearrangement a mixture of 4,5-dihydropyrazoles 3a-c, 3-pyrazolecarbaldehyde anils 4a-d, and 3-pyrazolecarbaldehydes 5a-c.Compounds 3 can be deaminated to give 4 which can be hydrolyzed to yield the 3-pyrazolecarbaldehydes 5. - The sydnones 6a,b react similarey with 2a to give a mixture of 4-pyrazolecarbaldehyde anils 7a,b and 4-pyrazolecarbaldehydes 8a,b.The structural assignments are based on spectroscopic and X-ray diffraction data.