98700-50-6

Basic information

• Product Name: 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: BUTTPARK 146\18-30;5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE;5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE;4-Formyl-5-methyl-1-phenylpyrazole;5-Methyl-1-phenyl-4-pyrazolecarboxaldehyde;5-methyl-1-phenylpyrazole-4-carbaldehyde
• CAS NO: 98700-50-6
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 98700-50-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 76 °C
• Boiling Point: 326.5°Cat760mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.000215mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(98700-50-6)
• EPA Substance Registry System: 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(98700-50-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• WGK Germany: 3
• Hazardous Substances Data: 98700-50-6(Hazardous Substances Data)

Usage

Uses

Reactant for:Synthesis of (aminomethyl)pyrazoles by reductive amination as Smoothened antagonists for hair inhibitionSynthesis of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidinePreparation of pharmacologically active dialkylamino(phenyl-1H-pyrazolyl)butanols

InChI:InChI=1/C11H10N2O/c1-9-10(8-14)7-12-13(9)11-5-3-2-4-6-11/h2-8H,1H3

Upstream product

• 98700-49-3 4-(4-Fluorophenylimino)methyl-5-methyl-1-phenyl-1H-pyrazole 
• 153863-35-5 (5-methyl-1-phenyl-1H-pyrazol-4-yl)methanol 
• 100-63-0 phenylhydrazine 
• 89193-16-8 ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate 
• 59-88-1 phenylhydrazine hydrochloride 
• 3483-16-7 4-methyl-3-phenyl-sydnone 
• 98700-38-0 4-[3-(4-Fluoro-phenyl)-5-methylene-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine 

Downstream Products

• 1245469-44-6 C₂₁H₂₂FN₃O₂ 
• 1245469-37-7 C₂₂H₂₆N₄O 
• 1245469-36-6 C₂₂H₂₃F₃N₄ 
• 1204423-67-5 ethyl 2-fluoro-3-(5-methyl-1-phenylpyrazol-4-yl)acrylate 
• 1204423-71-1 C₁₃H₁₃FN₂O₂ 
• 1204423-69-7 Ethyl 2-fluoro-3-(5-methyl-1-phenylpyrazol-4-yl)propionate 
• 193747-18-1 (5-Methyl-1-phenyl-1H-pyrazol-4-yl)-phenyl-methanol 

Relevant articles and documents

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

1,6 - SUBSTITUTED (3R,6R) -3- (2,3-DIHYDRO-1H-INDEN-2-YL)-2,5-PIPERAZINEDIONE DERIVATIVES AS OXYTOCIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PRE-TERM LABOUR, DYSMENORRHEA AND ENDOMETRIOSIS

The present invention relates to compound S of Formula (I).

ν-Triazolines, XXIV-Pyrazolecarbaldehydes from 5-Amino-4,5-dihydro-4-methylene-ν-triazoles and Sydnones

The sydnones 1a-c react with the 4,5-dihydro-ν-triazoles 2a-c by long refluxing at 110-140 deg C affording via non-isolable adducts with elimination of CO2 and N2 and rearrangement a mixture of 4,5-dihydropyrazoles 3a-c, 3-pyrazolecarbaldehyde anils 4a-d, and 3-pyrazolecarbaldehydes 5a-c.Compounds 3 can be deaminated to give 4 which can be hydrolyzed to yield the 3-pyrazolecarbaldehydes 5. - The sydnones 6a,b react similarey with 2a to give a mixture of 4-pyrazolecarbaldehyde anils 7a,b and 4-pyrazolecarbaldehydes 8a,b.The structural assignments are based on spectroscopic and X-ray diffraction data.