98720-16-2

Upstream product

• 870-63-3 prenyl bromide 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 98720-24-2 (2R,3S)-6-[1-[5-Bromo-2-(3-methyl-but-2-enyloxy)-phenyl]-meth-(Z)-ylidene]-3,4-dimethyl-2-phenyl-[1,4]oxazepane-5,7-dione 
• 98720-24-2 (2R,3S)-6-[1-[5-Bromo-2-(3-methyl-but-2-enyloxy)-phenyl]-meth-(E)-ylidene]-3,4-dimethyl-2-phenyl-[1,4]oxazepane-5,7-dione 
• 163434-34-2 5-bromo-2-(3-methyl-2-butenyloxy)benzylidenemalonic acid dimethyl ester 
• 206664-32-6 2-methyl-4-[2-(1-hydroxyprop-2-yn-1-yl)-4-bromophenoxy]but-2-ene 
• 1402344-74-4 C₂₀H₁₇BrO₃ 
• 1402344-73-3 C₂₁H₁₉BrO₄ 
• 1456793-11-5 (Z)-2-(5-bromo-2-(3-methylbut-2-enyloxy)benzylidene)-6-hydroxybenzofuran-3(2H)-one 
• 98720-19-5 C₂₅H₂₆BrNO₄ 

Relevant academic research and scientific papers

Enantioselective alkynylation reactions to aldehydes: The effects of aromatic substituents upon the enantioselectivity

Asymmetric alkynylation reactions to linear alkyl and substituted aromatic aldehydes have been accomplished in good yields and with a range of selectivities. For aromatic aldehydes we observed that the selectivity of the alkynylation reaction appears to d

A nickel(ii)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes

A highly diastereo- and enantioselective intramolecular Alder-ene reaction with an alkene as the enophile has been developed by using a chiral N,N′-dioxide/nickel(ii) complex as the catalyst. This protocol provides a facile route towards the synthesis of diverse 3,4-disubstituted chroman, tetrahydroquinoline, piperidine and thiochroman derivatives in high yields with good to excellent diastereo- and enantioselectivities.

Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors

On the basis of previous pharmacophore modeling studies of naphthoquinones derivatives, we have designed and synthesized a new set of pyranonaphthoquinones. These compounds were obtained through a direct and highly efficient approach based on an intramole

A diastereoselective cobalt-mediated synthesis of benzopyrans using a novel variation of an intramolecular Nicholas reaction in the key cyclisation step: Optimisation and biological evaluation

A range of novel intramolecular cyclisation reactions between an organocobalt stabilised cation and a trisubstituted alkene have been accomplished that provide a concise route for the diastereoselective synthesis of a range of functionalised benzopyrans. In addition to the usual Lewis acids employed in the Nicholas reaction our studies have identified several other reagents for effecting the cyclisation reaction. In some examples sub-stoichiometric quantities of Lewis acid were successfully employed. These studies were concluded with a biological evaluation of specific derivatives, conducted by comparing their activity with the antihypertensive agent cromakalim 2, a drug whose mode of action is known to occur via the modulation of potassium channel activity.

INTRAMOLECULAR ENE REACTIONS VS COMPETITIVE PERICYCLIC PROCESSES: THE EFFECT OF SOLVENTS AND SALTS ON THE REACTION OF 5-BROMO-2-(3-METHYL-2-BUTENYLOXY)BENZYLIDENEMALONIC ACID DIMETHYL ESTER

The reactivity of 5-bromo-2-(3-methyl-2-butenyloxy)benzylidene malonic acid dimethyl ester (3) was studied in several reaction media.In aprotic solvents intramolecular ene reaction (IER) occurred to give cis and trans chroman derivatives (4) and (5), and