98722-37-3

Upstream product

• 101445-16-3 N-(2-carboxy-benzoyl)-4-nitro-phenylalanine 
• 1991-83-9 4-nitrophenylalanine 
• 85-44-9 phthalic anhydride 
• 64-17-5 ethanol 
• 60666-01-5 (RS)-N-phthaloyl-p-nitrophenylalanine 
• 93963-19-0 N-(2-carboxy-benzoyl)-4-nitro-DL-phenylalanine ethyl ester 
• 780004-06-0 C₁₁H₁₄N₂O₄ 
• 147065-06-3 (R)-4-nitrophenyl-alanine-hydrochloride 
• 88546-12-7 methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate 
• 555-16-8 4-nitrobenzaldehdye 
• 100-14-1 4-nitrobenzyl chloride 
• 855633-22-6 (4-nitro-benzyl)-phthalimido-malonic acid diethyl ester 
• 131175-70-7 (R)-N-phthaloyl-p-nitrophenylalanine 
• 93963-19-0 N-(2-carboxy-benzoyl)-4-nitro-D-phenylalanine ethyl ester 

Downstream Products

• 116604-68-3 4-dimethylamino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 1195524-16-3 4-amino-N,N-phthaloyl-D-phenylalanin-ethyl ester 
• 93942-39-3 C₂₃H₂₄Cl₂N₂O₄ 
• 98844-19-0 4-amino-N,N-phthaloyl-DL-phenylalanin-ethyl ester 

Relevant academic research and scientific papers

Melphalan intermediate and preparation method thereof

The invention discloses a Melphalan intermediate and a preparation method thereof. The Melphalan intermediate is prepared by acidifying a compound p-nitrobenzaldehyde under the action of methanol, a hydrochloric acid solvent, etc. The preparation method has a route with mild reaction conditions, is higher than an existing preparation method in yield, is economical and effective, and is suitable for large-scale industrial production. The synthesis route is as shown in the description.