98737-45-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 125225-54-9 (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide 
• 145761-24-6 Methanesulfonic acid (R)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 
• 135130-98-2 (4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone 
• 145285-56-9 (E)-ethyl 6-phenylhex-4-enoate 
• 98818-40-7 (4R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 98737-43-0 (2S,4R,5S)-2-Benzyl-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenylhexanoic acid 

Downstream Products

• 331767-03-4 tert-butyl (1S,2R,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 144163-44-0 (2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 210224-13-8 (S)-4-[(2S,4R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoylamino]-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid benzyl ester 
• 210224-09-2 {(1S,2R,4S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(S)-3-carbamoyl-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-propylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 210224-17-2 {(1S,2R,4S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(1S,2S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: Enantioselective synthesis of the core unit of ritonavir

An enantioselective synthesis of the dipeptide isostere of ritonavir has been accomplished utilizing Sharpless asymmetric hydroxylation as the key step.

Peptide inhibitors of aspartic proteinases with hydroxyethylene isostere replacement of peptide bond. II. Preparation of pseudotetrapeptides derived from diastereoisomeric 5-amino-2-benzyl-4-hydroxy-6-phenylhexanoic acids

Twelve pseudotetrapeptides, Boc-NHCH(CH2Ph)CH(OH)CH2CH(CH2Ph) CO-Xaa-Phe-NH2 9-11, were prepared by [(benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphatemediated couplings of diastereoisomer