125225-54-9

Upstream product

• 151692-01-2 3-((4R,5R)-5-Benzyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid 
• 6738-06-3 phenylethynylmagnesium bromide 
• 61550-02-5 (furan-2-yloxy)-trimethylsilane 
• 122-78-1 phenylacetaldehyde 
• 133337-03-8 (4R,5R)-4-Benzyl-5-but-3-enyl-2,2-dimethyl-[1,3]dioxolane 
• 133337-02-7 (2R,3R)-2,3-isopropylidendioxy-6-hepten-1-ol 
• 140844-91-3 (4R,5R)-3-(2,2-dimethyl-5-phenylmethyl-1,3-dioxolan-4-yl)propan-1-ol 
• 140844-83-3 (4S)-hydroxy-6-phenyl-5-hexynoic acid methyl ester 
• 140844-83-3 4-hydroxy-6-phenyl-5-hexynoic acid methyl ester 
• 140844-87-7 (R,Z)-6-t-butyldimethylsilyloxy-1-phenyl-1-hexen-3-ol 
• 140844-84-4 (-)-(R)-γ-(2-phenylethynyl)-γ-butyrolactone 
• 59700-95-7 (E)-(R)-6-Phenyl-hex-5-ene-1,4-diol 
• 140844-92-4 (4R,5R)-3-(2,2-dimethyl-5-phenylmethyl-1,3-dioxolan-4-yl)propyl 3,5-dinitrobenzoate 
• 140844-90-2 [3-((R)-5-Benzyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propoxy]-tert-butyl-dimethyl-silane 

Downstream Products

• 145761-24-6 Methanesulfonic acid (R)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 
• 135130-98-2 (4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 98818-40-7 (4R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 144163-44-0 (2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane 
• 98737-45-2 (2S,4R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid 
• 331767-03-4 tert-butyl (1S,2R,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 125225-53-8 (R)-5-((S)-1-Hydroxy-2-phenyl-ethyl)-dihydro-furan-2-one 
• 133337-04-9 Acetic acid (S)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 

Relevant academic research and scientific papers

Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: Enantioselective synthesis of the core unit of ritonavir

An enantioselective synthesis of the dipeptide isostere of ritonavir has been accomplished utilizing Sharpless asymmetric hydroxylation as the key step.

Synthesis of the (4R,5R)-Isomer of 5-Hydroxy-6-phenyl-4-hexanolide, a Lateral Root-inducing Substance Isolated from Erwinia quercina

Lipase-catalyzed enantioselective lactonization of racemic methyl 6-phenyl-4-hydroxy-5-hexynoate worked well to afford (R)-6-phenyl-5-hexyn-4-olide (42 percent yield, 81 percent e.e.).The e.e. of the product was enhanced to 97 percent by the repetition of

A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (-)- and (+)-muricatacin

Both enantiomers of hydroxy γ-lactones have been prepared highly enantioselectively (92-99% ee) using either AD-mix-β or AD-mix-α with both β,γ- and γ,δ-unsaturated esters. The method is exemplified by the three-step synthesis of (-) and (+)-muricatacin i

Synthesis of Lateral Root-Inducing Compounds Using an Efficient Coupling Reaction of Chiral Triflates

Lateral root-inducing compounds, isolated from the bacterium Erwinia quercina, have been synthesized by using a coupling reaction of chiral triflates derived from L- or D-tartrates and their biological activities examined.

DIASTEREOSELECTIVITY IN THE DIRECTED ALDOL CONDENSATION OF 2-TRIMETHYLSILOXYFURAN WITH ALDEHYDES. A STEREODIVERGENT ROUTE TO THREO AND ERYTHRO δ-HYDROXY-γ-LACTONES

Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).