125225-54-9

Basic information

• Product Name: (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide
• Synonyms: (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide
• CAS NO: 125225-54-9
• Molecular Weight: 206.241
• Mol File: 125225-54-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide(125225-54-9)
• EPA Substance Registry System: (4R,5R)-5-hydroxy-6-phenyl-4-hexanolide(125225-54-9)

Safety Data

• Hazardous Substances Data: 125225-54-9(Hazardous Substances Data)

Upstream product

• 61550-02-5 (furan-2-yloxy)-trimethylsilane 
• 122-78-1 phenylacetaldehyde 
• 133337-03-8 (4R,5R)-4-Benzyl-5-but-3-enyl-2,2-dimethyl-[1,3]dioxolane 
• 133337-02-7 (2R,3R)-2,3-isopropylidendioxy-6-hepten-1-ol 
• 140844-91-3 (4R,5R)-3-(2,2-dimethyl-5-phenylmethyl-1,3-dioxolan-4-yl)propan-1-ol 
• 140844-83-3 (4S)-hydroxy-6-phenyl-5-hexynoic acid methyl ester 
• 140844-83-3 4-hydroxy-6-phenyl-5-hexynoic acid methyl ester 
• 140844-87-7 (R,Z)-6-t-butyldimethylsilyloxy-1-phenyl-1-hexen-3-ol 
• 140844-84-4 (-)-(R)-γ-(2-phenylethynyl)-γ-butyrolactone 
• 59700-95-7 (E)-(R)-6-Phenyl-hex-5-ene-1,4-diol 
• 140844-92-4 (4R,5R)-3-(2,2-dimethyl-5-phenylmethyl-1,3-dioxolan-4-yl)propyl 3,5-dinitrobenzoate 
• 140844-90-2 [3-((R)-5-Benzyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propoxy]-tert-butyl-dimethyl-silane 
• 140844-89-9 (3R)-6-t-butyldimethylsilyloxy-1,2-epoxy-1-phenylhexane-3-ol 
• 140844-93-5 3-((4R,5R)-5-Benzyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionaldehyde 

Downstream Products

• 125225-53-8 (R)-5-((S)-1-Hydroxy-2-phenyl-ethyl)-dihydro-furan-2-one 
• 133337-04-9 Acetic acid (S)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 
• 331767-03-4 tert-butyl (1S,2R,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 98737-45-2 (2S,4R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid 
• 144163-44-0 (2S,3S,5S)-3-hydroxy-2,5-bisamino-1,6-diphenylhexane 
• 98818-40-7 (4R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 135130-98-2 (4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone 
• 145761-24-6 Methanesulfonic acid (R)-1-((R)-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl ester 

Relevant articles and documents

Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: Enantioselective synthesis of the core unit of ritonavir

An enantioselective synthesis of the dipeptide isostere of ritonavir has been accomplished utilizing Sharpless asymmetric hydroxylation as the key step.

A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (-)- and (+)-muricatacin

Both enantiomers of hydroxy γ-lactones have been prepared highly enantioselectively (92-99% ee) using either AD-mix-β or AD-mix-α with both β,γ- and γ,δ-unsaturated esters. The method is exemplified by the three-step synthesis of (-) and (+)-muricatacin i

DIASTEREOSELECTIVITY IN THE DIRECTED ALDOL CONDENSATION OF 2-TRIMETHYLSILOXYFURAN WITH ALDEHYDES. A STEREODIVERGENT ROUTE TO THREO AND ERYTHRO δ-HYDROXY-γ-LACTONES

Threo and erythro-δ-hydroxy-4a,β-unsaturated γ-lactones are obtained with useful diastereoselection by condensing 2-trimethylsiloxyfuran and aldehydes by variying the reaction conditions.A stereomechanistic rationale is presented together with a practical two-step synthesis of the threo and erythro 5-hydroxy-4-decanolides (L-factors).