98786-86-8

Basic information

• Product Name: 3-AMINO-5-BROMO-PYRIDIN-2-OL
• Synonyms: 3-AMINO-5-BROMO-2-HYDROXYPYRIDINE;3-AMINO-5-BROMO-PYRIDIN-2-OL;2-Pyridinol,3-amino-5-bromo- (6CI);3-Amino-5-bromo-2(1H)-pyridinone;3-AMino-5-broMopyridin-2(1H)-one;3-Amino-5-bromo-1H-pyridin-2-one;3-Amino-5-bromo-2-hydroxypyridine≥ 97% (HPLC);3-Amino-5-bromo-2-pyridinol
• CAS NO: 98786-86-8
• Molecular Formula: C₅H₅BrN₂O
• Molecular Weight: 189.01
• Product Categories: Heterocycle-Pyridine series
• Mol File: 98786-86-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 182-184 °C
• Boiling Point: 295.1°Cat760mmHg
• Flash Point: 132.3°C
• Appearance: /Solid
• Density: 1.826g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.81±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-BROMO-PYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-BROMO-PYRIDIN-2-OL(98786-86-8)
• EPA Substance Registry System: 3-AMINO-5-BROMO-PYRIDIN-2-OL(98786-86-8)

Safety Data

• Hazardous Substances Data: 98786-86-8(Hazardous Substances Data)

Upstream product

• 6945-68-2 5-bromo-3-nitro-pyridin-2-ylamine 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 

Downstream Products

• 108870-77-5 6-bromo-2-phenyloxazolo[5,4-b]pyridine 
• 102170-55-8 N-(5-bromo-2-hydroxy-[3]pyridyl)-acetamide 
• 869645-73-8 N-(5-bromo-2-hydroxypyridin-3-yl)-4-(trifluoromethyl)benzamide 
• 1198319-39-9 6-bromooxazolo[5,4-b]pyridin-2-amine 
• 1616402-87-9 C₁₂H₁₀BrFN₂O 
• 1616401-81-0 3-amino-5-(3,5-dimethylisoxazol-4-yl)-1-(4-fluorobenzyl)pyridin-2(1H)-one 
• 1616402-99-3 C₁₈H₂₂BClN₂O₃ 
• 1616402-06-2 3-amino-1-(4-chlorobenzyl)-5-(3-(hydroxymethyl)-5-methylisoxazol-4-yl)pyridin-2(1H)-one 
• 1616402-98-2 C₁₂H₁₀BrClN₂O 
• 116081-18-6 6-bromo-2-methyloxazolo[5,4-b]pyridine 

Relevant articles and documents

Synthesis and applications of 3-amino-2-hydroxypyridine

The invention discloses synthesis and applications of 3-amino-2-hydroxypyridine. The synthesis steps comprise: (1) dissolving 2-hydroxy-3-nitro-5-bromopyridine in a solvent, stirring, adding the mixture of iron powder and hydrochloric acid, carrying out a reaction for 0.5-1 h, and carrying out post-treatment to obtain 2-hydroxy-3-amino-5-bromopyridine; and (2) dissolving the 2-hydroxy-3-amino-5-bromopyridine obtained in the step (1) in an alkaline solution, adding strontium carbonate, introducing hydrogen into a reaction bottle, carrying out a reaction for a certain time, and carrying out conventional treatment to obtain 3-amino-2-hydroxypyridine. According to the present invention, the production cost is substantially reduced, and the obtained 3-amino-2-hydroxypyridine has the high purityand can be directly used in the next step.

Pharmaceutical compositions for CNS and other disorders

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.