98789-94-7

Upstream product

• 78-94-4 methyl vinyl ketone 
• 98789-90-3 ((E)-4-Dodec-1-enyl)-morpholine 
• 1198748-04-7 2-(3-oxobutyl)dodecanal 
• 112-44-7 undecylaldehyde 
• 2855-19-8 Decyl-oxiran 
• 112-54-9 Dodecanal 

Downstream Products

• 1198748-05-8 C₂₂H₃₂F₂O 
• 1309378-30-0 4-n-decyl-1-phenylcyclohex-2-en-1-ol 
• 345936-71-2 4-n-decylcyclohexyl benzene 
• 98789-95-8 4-decylcyclohexanone 

Relevant academic research and scientific papers

Phase behavior of some mono-substituted ferrocene- and [3]ferrocenophane- containing nematics with the cyclohexane ring in the rigid core

Generally, incorporation of the cyclohexane rings into the rigid core of rod-like mesogens leads to improved technological parameters, i.e. low viscosity, ambient transition temperatures and stability of the nematic state. Taking this into consideration,

Novel tetrahedratic smectic C and nematic mesophases in unsymmetrically 1,1-bis-substituted ferrocenomesogens

Non-conventional mesophases have been observed in novel ferrocene-containing liquid crystals. The formation of helical and garland-like superstructures, and spontaneous resolution into macroscopic chiral domains occur in the lamellar mesophase. The nemati

Intramolecular Cooperative Reactions of 1,2-Bis(diazoketone)s. The First Syntheses of trans-Hydro-1H-2-inden-1-ones

The intramolecular cooperative reactions of 1,2-bis(diazoketone)s initiated by the Wolff rearrangement of α-diazoketones have been investigated.Under thermal conditions, 1,2-bis(diazoketone)s are efficiently transformed into 2-cyclopenten-1-one derivatives with complete stereospecificity.Thus, a most extraordinary result is reported, that trans-hydro-2-inden-1-ones (1-3) were synthesized for the first time from trans-1,2-bis(diazoketone)s (5, 11, and 12), respectively.The unprecedented trans-hydroindenone structure was confirmed by X-ray analysis of 3 as well as 1H NMR analysis and was supported by ab initio molecular orbital calculations.The same reactions were also carried out under photochemical conditions and were applied to 1,3-bis(diazoketone)s, giving 2-cyclohexen-1-one derivatives.

Novel Synthesis of trans-Hydroindenones by Thermal Reaction of α,ω-Bis(diazo)diketones

Thermal reaction of α,ω-bis(diazo)diketones gives α,β-unsaturated cycloalkenones including unsubstituted trans-hydroindenones, which were difficult to access by the conventional synthetic reactions.

Antiarthritic and suppressor cell inducing activity of azaspiranes: Structure-function relationships of a novel class of immunomodulatory agents

Spirogermanium (1;8,8-diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamin e dihydrochloride) is a potent cytotoxic agent in vitro which has demonstrated limited activity in experimental animal tumor models. Subsequently, it has been reported that spirogermanium has antiarthritic and suppressor cell-inducing activity. We have synthesized a series of substituted 8-hetero-2-azaspiro[4.5]decane and 9-hetero-3-azaspiro[5.5]undecane analogues of spirogermanium to identify the heteroatom requirements for in vivo antiarthritic and suppressor cell-inducing activity. This structure-activity relationship study has identified that appropriately substituted silicon and carbon analogues of spirogermanium retain both antiarthritic and immunosuppressive activity, with the 8,8-dipropyl (carbon) analogue being among the most active. Following the identification of N,N-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dihydrochloride (9) as more active analogue than spirogermanium, a series of 8,8-dipropyl analogues with various amine substituents were synthesized. A number of these analogues had activity similar to that of 9. A correlation between activity in the adjuvant arthritic rat and the ability to induce suppressor cells (r = 0.894, p0.001) suggests an association between the two pharmacologic effects. While the precise biochemical mechanism(s) for the pharmacological activity is unclear, these data suggest that compounds within this series, e.g., N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride, may provide effective therapy in diseases of autoimmune origin and/or the prevention of rejection in tissue transplantation.

Aliphatic Liquid Crystals, 2. Some Nematic Derivatives of all-trans-Perhydrophenanthrene

A stereoselective synthesis of the all-trans-7-alkylperhydro-2-phenanthrenols 15a-f in 11 steps and 28 liquid crystalline esters 16 of 15a-f are described, additionally some further derivatives of 7-alkylperhydro-2-phenanthrenol.An X-ray structure analysis of ester 16ec is reported.