98791-67-4 Usage
Description
BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(?)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.
Uses
(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.
Biological Activity
L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).
Check Digit Verification of cas no
The CAS Registry Mumber 98791-67-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,9 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98791-67:
(7*9)+(6*8)+(5*7)+(4*9)+(3*1)+(2*6)+(1*7)=204
204 % 10 = 4
So 98791-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m1/s1
