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CAS

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98791-67-4

R(+)-BAY K 8644, also known as (R)-(+)-BAY-K-8644, is an enantiomer of BAY-K-8644 that acts as an L-type calcium channel blocker. It possesses negative inotropic and vasodilatory effects at a concentration of 1 μM. R(+)-BAY K 8644 is one of the two enantiomers of BAY-K-8644, with the other being (S)-(-)-BAY K 8644, which has opposite actions as a calcium channel activator.

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  • 98791-67-4 Structure

  • Basic information

    1. Product Name: R(+)-BAY K 8644
    2. Synonyms: (4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER;R(+)-BAY K 8644;R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE;(+/-)-BAY K 8644, 0 TO 5 °C;R(+)-BAY K 8644 98% 0 C;(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
    3. CAS NO:98791-67-4
    4. Molecular Formula: C16H15F3N2O4
    5. Molecular Weight: 356.3
    6. EINECS: N/A
    7. Product Categories: Calcium channel
    8. Mol File: 98791-67-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 429.2°C at 760 mmHg
    3. Flash Point: 213.4°C
    4. Appearance: yellow/solid
    5. Density: 1.37g/cm3
    6. Vapor Pressure: 1.43E-07mmHg at 25°C
    7. Refractive Index: 1.542
    8. Storage Temp.: 2-8°C
    9. Solubility: H2O: slightly soluble
    10. CAS DataBase Reference: R(+)-BAY K 8644(CAS DataBase Reference)
    11. NIST Chemistry Reference: R(+)-BAY K 8644(98791-67-4)
    12. EPA Substance Registry System: R(+)-BAY K 8644(98791-67-4)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 98791-67-4(Hazardous Substances Data)

98791-67-4 Usage

Uses

Used in Pharmaceutical Research:
R(+)-BAY K 8644 is used as a research tool for studying the effects of L-type calcium channel blockers on various physiological processes. Its ability to block L-type calcium channels makes it valuable in investigating the role of these channels in cardiac function, muscle contraction, and neurotransmitter release.
Used in Drug Development:
R(+)-BAY K 8644 is utilized in the development of new drugs targeting L-type calcium channels for the treatment of various cardiovascular and neurological disorders. Its inhibitory action on these channels can help in the management of conditions such as hypertension, angina, and certain types of arrhythmias.
Used in Toxicological Studies:
R(+)-BAY K 8644 is employed in toxicological research to understand the potential side effects and safety profiles of L-type calcium channel blockers. This information is crucial for the development of safer and more effective drugs in this class.
Used in Neurological Research:
R(+)-BAY K 8644 is used as a research compound to study the role of L-type calcium channels in neurological functions and disorders. Its ability to block these channels can provide insights into the mechanisms underlying neurological conditions such as epilepsy, Parkinson's disease, and Alzheimer's disease.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

Check Digit Verification of cas no

The CAS Registry Mumber 98791-67-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,9 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98791-67:
(7*9)+(6*8)+(5*7)+(4*9)+(3*1)+(2*6)+(1*7)=204
204 % 10 = 4
So 98791-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m1/s1

98791-67-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name R(+)-BAY K 8644

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98791-67-4 SDS

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