98792-24-6Relevant academic research and scientific papers
A NOVEL SYNTHESIS AND TRANSFORMATIONS OF 1H-PYRAZINO-1,3,4-THIADIAZINE DERIVATIVES
Koren, Bozidar,Stanovnik, Branko,Tisler, Miha
, p. 913 - 925 (2007/10/02)
1,4-Disubstituted thiosemicarbazides 2, 4, and 9 cyclize thermally into 1H-pyrazino-1,3,4-thiadiazine derivatives 3,5,6 and 8.These can be converted under mild reaction conditions into derivatives of the same bicyclic system 10, 17, and 21.However, under acidic or alkaline conditions a cleavagte of the C3-S bond of the 1,3,4-thiadiazine ring is taking place to give either the 1,4-disubstituted semicarbazide 12, or rearranged products, derivatives of s-triazolopyrazine, 7, 11, 13, 14, 15, 16, 18, 22, 23 and 24.
